| Anti-yo antibody associated with occult fallopian tube carcinoma. | |
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MedLine Citation:
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PMID: 21979588 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This is the case report of a 61-year-old woman who presented with progressive diplopia and ataxia. Her cerebrospinal fluid revealed high titers of anti-Yo (PCA-1) antibody and a magnetic resonance imaging with contrast showed cerebellar degeneration. Extensive imaging workup was negative for malignancy and she was otherwise asymptomatic. Given the association between anti-Yo antibodies and gynecologic malignancies, she underwent a bilateral salpingo-oophorectomy and cancer staging. Extensive section of the fimbriated end of the fallopian tube revealed a stage 1, microscopic serous adenocarcinoma. After surgery, her anti-YO titers fell and plans were made for adjuvant chemotherapy. Her neurologic symptoms are not expected to substantially improve, illustrating the urgent need for early surgical investigation in cases of paraneoplastic syndrome, even in the absence of imaging evidence of a lesion. |
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Authors:
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Kevin J Selby; Jeremy Warner; Samuel Klempner; Panagiotis A Konstantinopoulos; Jonathan L Hecht |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Volume: 30 ISSN: 1538-7151 ISO Abbreviation: Int. J. Gynecol. Pathol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214845 Medline TA: Int J Gynecol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 536-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Beth-Israel Deaconess Medical Center, Boston, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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