Document Detail


Anti-viral and immunomodulatory effects of interferon-alpha on cultured lymphocytes from patients with human T lymphotropic virus type I-associated myelopathy (HAM/TSP).
MedLine Citation:
PMID:  7593557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In contrast to therapeutic benefits of interferon-alpha (IFN-alpha) in patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), little is known about the mechanisms underlying its clinical efficacy. To investigate the anti-viral and/or immunomodulatory properties of IFN-alpha in HTLV-I infection, the effects of IFN-alpha on HTLV-I-induced in vitro phenomena were evaluated. In vitro activation of HTLV-I in fractionated CD4+ T lymphocyte-rich cells (CD4+ cells) could be demonstrated by increased thymidine incorporation into the cells, detection of proviral HTLV-I and viral RNA, and by assays of reverse transcriptase activities in culture supernatants. T cell immune responses were evaluated by thymidine incorporation into CD8+ T lymphocyte-rich cells (CD8+ cells) responding to cultured and irradiated autologous CD4+ cells possessing HTLV-I antigens. It could be shown that IFN-alpha suppressed both the in vitro activation of HTLV-I and the CD8+ cell response. Moreover, 1 day supplementation of IFN-alpha as a pretreatment was sufficient for the induction of these properties. These findings, together with the clinical efficacy of IFN-alpha administration in patients with HAM/TSP, support the view that viral activation and T cell responses are critical components in the pathogenic processes involved in HAM/TSP.
Authors:
S Ijichi; S Izumo; M Nagai; K Shinmyozu; W W Hall; M Osame
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  61     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-11-30     Completed Date:  1995-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  IM; X    
Affiliation:
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / pharmacology*
Base Sequence
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Cells, Cultured
DNA Primers / chemistry
HTLV-I Antigens / analysis
Humans
Interferon-alpha / pharmacology*
Lymphocyte Activation / drug effects
Molecular Sequence Data
Paraparesis, Tropical Spastic / immunology*
RNA-Directed DNA Polymerase / analysis
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/DNA Primers; 0/HTLV-I Antigens; 0/Interferon-alpha; EC 2.7.7.49/RNA-Directed DNA Polymerase

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