| Anti-vascular endothelial growth factor antibody and nimustine as combined therapy: effects on tumour growth and angiogenesis in human glioblastoma xenografts. | |
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MedLine Citation:
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PMID: 12626127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effectiveness of vascular endothelial growth factor (VEGF) blockade alone and in combination with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU, nimustine), a cytotoxic agent commonly used in the treatment of malignant gliomas, to eradicate tumors of human glioblastoma cell lines implanted in SCID (severe combined immunodeficiency) mice. ACNU, but not cisplatin and etoposide, elevated VEGF expression in a glioma cell line in vitro. VEGF antibody alone inhibited glioma growth in vivo as a result of angiogenesis inhibition. The combination with ACNU resulted in an additive effect for inhibition of glioma growth. ACNU also induced VEGF up-regulation in glioma tissues, which was decreased with VEGF antibody treatment. One of the mechanisms of the additive effect of the VEGF antibody and ACNU combination is the blockade of VEGF up-regulation induced by ACNU. As such, the combination of antiangiogenic therapy with conventional therapy is promising for glioma treatment in the future. |
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Authors:
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Shingo Takano; Koji Tsuboi; Akira Matsumura; Tadao Nose |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuro-oncology Volume: 5 ISSN: 1522-8517 ISO Abbreviation: Neuro-oncology Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-03-10 Completed Date: 2003-06-11 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 100887420 Medline TA: Neuro Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Ibaraki 305-8575, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / administration & dosage, therapeutic use* Antineoplastic Combined Chemotherapy Protocols / administration & dosage* Endothelial Growth Factors / antagonists & inhibitors*, biosynthesis, immunology* Glioblastoma / drug therapy*, metabolism Humans Intercellular Signaling Peptides and Proteins / biosynthesis, immunology* Lymphokines / antagonists & inhibitors*, biosynthesis, immunology* Male Mice Mice, SCID Neoplasm Transplantation Neovascularization, Pathologic / drug therapy* Nimustine / administration & dosage*, therapeutic use* Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Xenograft Model Antitumor Assays / methods |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Endothelial Growth Factors; 0/Intercellular Signaling Peptides and Proteins; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 42471-28-3/Nimustine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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