| Anti-tumour effects of elatol, a marine derivative compound obtained from red algae Laurencia microcladia. | |
| | |
MedLine Citation:
|
PMID: 22775218 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objectives This paper aims to evaluate the anti-tumour properties of elatol, a compound (sesquiterpene) isolated from algae Laurencia microcladia. Methods In-vitro and in-vivo anti-tumour properties of elatol were investigated using: MTT assays to assess the cytotoxic effects; flow cytometry analysis to examine the cell cycle and apoptosis; Western blot analysis for determination of the expression of cell cycle and apoptosis proteins; and study of in-vivo tumour growth in mice (C57Bl6 mice bearing B16F10 cells). Key findings Elatol exhibited a cytotoxic effect, at least in part, by inducing cell cycle arrest in the G(1) and the sub-G(1) phases, leading cells to apoptosis. Western blot analysis demonstrated that elatol reduced the expression of cyclin-D1, cyclin-E, cyclin-dependent kinase (cdk)2 and cdk4. A decrease in bcl-xl and an increase in bak, caspase-9 and p53 expression was also observed. In the in-vivo experiment, treatment with elatol was able to reduce tumour growth in C57Bl6 mice. Conclusions Elatol promotes a delay in the cell cycle, probably in the G(1) /S transition, activating the apoptotic process and this could be responsible, at least in part, for the in-vivo effects observed. Taken together, the in-vitro and in-vivo experiments suggested that elatol has anti-tumour properties. Further studies should be conducted to clarify the mechanism of action. |
| | |
Authors:
|
Andreza Campos; Christiane Borges Souza; Cintia Lhullier; Miriam Falkenberg; Eloir Paulo Schenkel; Rosa Maria Ribeiro-do-Valle; Jarbas Mota Siqueira |
Related Documents
:
|
22732498 - Why minimal is not optimal: driving the mammalian cell cycle--and drug discovery--with ... 22870388 - Quantitative single-molecule microscopy reveals that cenp-a(cnp1) deposition occurs dur... 1346968 - An inside look at a small cell. yeast cell biology sponsored by cold spring harbor labo... 17625968 - B cell modulation in rheumatology. 12677238 - Inhibition of the low density lipoprotein-induced vascular smooth muscle cell growth by... 17938168 - The essential cell division protein ftsn interacts with the murein (peptidoglycan) synt... |
Publication Detail:
|
Type: Journal Article Date: 2012-04-27 |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 64 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-07-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 1146-54 Citation Subset: IM |
Copyright Information:
|
© 2012 The Authors. JPP © 2012 Royal Pharmaceutical Society. |
Affiliation:
|
Department of Pharmacology Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageen...
Next Document: Antispasmodic effects of a new kaurene diterpene isolated from Croton argyrophylloides on rat airway...