Document Detail


Anti-tumorigenic chalcones.
MedLine Citation:
PMID:  8142919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13-acetate (TPA) in HeLa cells was adopted as a screening test for anti-tumor-promoting effect. In vivo experimental mouse skin tumors initiated by dimethylbenz[a]-anthracene (DMBA) and promoted by TPA were used to test the anti-tumor-promoting effect of chalcones. In the results, 3'- and 4'-methyl-3-hydroxychalcone showed the highest potency in inhibiting tumorigenesis. They also showed a remarkable inhibitory effect on the proliferation of HGC-27 cells derived from human gastric cancer. We discuss the structure-activity relationship, including stereo-chemical phototransformation, of some chalcone derivatives with reference to their ultraviolet (UV) and nuclear magnetic resonance (NMR) spectroscopic data.
Authors:
S Shibata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  12     ISSN:  1066-5099     ISO Abbreviation:  Stem Cells     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-29     Completed Date:  1994-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Affiliation:
Shibata Laboratory of Natural Medicinal Materials, Minophagen Pharmaceutical Company, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemistry,  pharmacology*
Chalcone / analogs & derivatives,  chemistry,  pharmacology*
Drug Screening Assays, Antitumor
Hela Cells
Humans
Mice
Time Factors
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 94-41-7/Chalcone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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