| Anti-tumorigenic chalcones. | |
| | |
MedLine Citation:
|
PMID: 8142919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
On the basis of our recent findings that licochalcone A isolated from Xin-jiang licorice showed anti-inflammatory and anti-tumorigenic activities, we synthesized more than 40 chalcone derivatives to examine their anti-tumorigenic activities. In vitro inhibitory activity against phosphorylation of phospholipids promoted by tetradecanoylphorbol-13-acetate (TPA) in HeLa cells was adopted as a screening test for anti-tumor-promoting effect. In vivo experimental mouse skin tumors initiated by dimethylbenz[a]-anthracene (DMBA) and promoted by TPA were used to test the anti-tumor-promoting effect of chalcones. In the results, 3'- and 4'-methyl-3-hydroxychalcone showed the highest potency in inhibiting tumorigenesis. They also showed a remarkable inhibitory effect on the proliferation of HGC-27 cells derived from human gastric cancer. We discuss the structure-activity relationship, including stereo-chemical phototransformation, of some chalcone derivatives with reference to their ultraviolet (UV) and nuclear magnetic resonance (NMR) spectroscopic data. |
| | |
Authors:
|
S Shibata |
Related Documents
:
|
6956909 - Tumor-promoter-resistant cells lack trisialoganglioside response. 16044159 - Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to c... 16054739 - Carcinogenic risks of dioxin: mechanistic considerations. 2766409 - Effect of chemical constituents from plants on 12-o-tetradecanoylphorbol-13-acetate-ind... 17192069 - Non-invasive imaging of carcinogen-induced early neoplasia using ultrahigh-resolution o... 12919959 - Osteopontin induction is required for tumor promoter-induced transformation of preneopl... 18413739 - Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-speci... 22919149 - Primary borderline mucinous neoplasm of the testis: a case report and literature review. 17961039 - Meningiomas: causes and risk factors. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Stem cells (Dayton, Ohio) Volume: 12 ISSN: 1066-5099 ISO Abbreviation: Stem Cells Publication Date: 1994 Jan |
Date Detail:
|
Created Date: 1994-04-29 Completed Date: 1994-04-29 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9304532 Medline TA: Stem Cells Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 44-52 Citation Subset: IM |
Affiliation:
|
Shibata Laboratory of Natural Medicinal Materials, Minophagen Pharmaceutical Company, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents / chemistry, pharmacology* Chalcone / analogs & derivatives, chemistry, pharmacology* Drug Screening Assays, Antitumor Hela Cells Humans Mice Time Factors Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 94-41-7/Chalcone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The use of animal models in cancer drug discovery and development.
Next Document: Highlight on the studies of anticancer drugs derived from plants in China.