Document Detail

Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay.
MedLine Citation:
PMID:  10378778     Owner:  NLM     Status:  MEDLINE    
In a search for anti-tumor-promoting agents, we carried out a primary screening of twenty-nine 8-substituted and four 6-substituted derivatives of 7-methoxycoumarins isolated from plants of the Murraya and/or Citrus species (Rutaceae), examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. This investigation indicated that the prenyl (3-methyl-2-butenyl) or 2-hydroxy-3-methylbutyl (or butenyl) unit as an isoprenoid moiety at C-8 on the 7-methoxycoumarin nucleus plays an important role in the anti-tumor-promoting activity. Some of the 8-substituted 7-methoxycoumarins isolated from Murraya species, murrangatin (7), minumicrolin (10) and chloticol (18), were found to significantly inhibit EBV-EA activation, and preserved the high viability of Raji cells, suggesting that 7, 10 and 18 might be valuable anti-tumor-promoting agents.
C Ito; M Itoigawa; H Furukawa; H Tokuda; Y Okuda; T Mukainaka; M Okuda; H Nishino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  138     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-01     Completed Date:  1999-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Cells, Cultured
Coumarins / pharmacology*
Herpesvirus 4, Human / drug effects*,  physiology
Structure-Activity Relationship
Tetradecanoylphorbol Acetate / antagonists & inhibitors*
Virus Activation / drug effects
Reg. No./Substance:
0/Antineoplastic Agents; 0/Coumarins; 16561-29-8/Tetradecanoylphorbol Acetate

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