| Anti-tumor effect of gallic acid on LL-2 lung cancer cells transplanted in mice. | |
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MedLine Citation:
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PMID: 11707653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring plant phenol, can induce apoptosis in four kinds of human lung cancer cell lines in vitro. The present study further investigated the in vivo anti-tumor effects of orally administered gallic acid. Gallic acid reduced cell viability of LL-2 mouse lung cancer cells in vitro dose dependently, with a 50% inhibitory concentration (IC50) value of around 200 microM. C57Black mice were transplanted with LL-2 cells, and administered gallic acid (1 mg/ml in drinking water, ad libitum) and/or cisplatin (4 mg/kg i.p. injection, once a week). The average weight of the transplanted tumors, obtained at 29 days after transplantation, in the mice of control, gallic acid-treated cisplatin-treated and cisplatin plus gallic acid-treated groups was 4.02, 3.65, 3.19 and 1.72 g, respectively. The average tumor weight of the mice treated with cisplatin combined with gallic acid was significantly smaller than that of the control group (p<0.05). The amount of apoptotic cells in the tumor tissues of mice treated with gallic acid and/or cisplatin was significantly higher than those of the control mice. Combination of gallic acid and cisplatin increased the tumor cell apoptosis compared with the treatment with cisplatin alone. The present findings suggest that the combination of gallic acid with an anti-cancer drug, including cisplatin, may be an effective protocol for lung cancer therapy. |
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Authors:
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M Kawada; Y Ohno; Y Ri; T Ikoma; H Yuugetu; T Asai; M Watanabe; N Yasuda; S Akao; G Takemura; S Minatoguchi; K Gotoh; H Fujiwara; K Fukuda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anti-cancer drugs Volume: 12 ISSN: 0959-4973 ISO Abbreviation: Anticancer Drugs Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-14 Completed Date: 2002-03-15 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 9100823 Medline TA: Anticancer Drugs Country: England |
Other Details:
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Languages: eng Pagination: 847-52 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Apoptosis / drug effects Cell Survival / drug effects Cisplatin / therapeutic use* DNA, Neoplasm / analysis Dose-Response Relationship, Drug Gallic Acid / therapeutic use* Lung Neoplasms / drug therapy*, pathology Mice Mice, Inbred C57BL Neoplasm Transplantation Tumor Cells, Cultured / drug effects |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 149-91-7/Gallic Acid; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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