Document Detail


Anti-salivary antibodies in primary Sjögren's syndrome.
MedLine Citation:
PMID:  7616459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Earlier studies have described an antibody that recognized salivary ductal epithelium in sera from 15-50% of patients with primary Sjögren's syndrome; however, the specific salivary antigen in those studies was not identified. The present study further investigated this unknown salivary antigen. Twenty-nine of 31 patients (94%) with primary Sjögren's syndrome demonstrated IgG antinuclear antibodies that bound to an epithelial cell line with ductal characteristics derived from a human salivary gland. Seventy-seven percent of these patients had serum antibodies that bound to ductal cells of normal human parotid tissue after formalin fixation. Western blots of cell extracts, immunofluorescence, and adsorption studies indicated that SS-A/Ro and SS-B/La were the antigens recognized in the salivary cell line. The pattern of fluorescence seen when anti-SS-B/La bound to normal parotid tissue was identical to the fluorescence pattern of the anti-salivary ductal antibodies described in earlier literature.
Authors:
J C Atkinson; L S Royce; R Wellner; S R Pillemer; D Bermudez; P C Fox
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  24     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-24     Completed Date:  1995-08-24     Revised Date:  2007-05-11    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  206-12     Citation Subset:  D; IM    
Affiliation:
Clinical Investigations Section, National Institute of Dental Research, Bethesda, MD 20892-1190, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Antinuclear / immunology*
Antibody Affinity
Autoantigens / isolation & purification*
Blotting, Western
Cell Line
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Epithelium / immunology
Female
Fluorescent Antibody Technique
Hela Cells
Humans
KB Cells
Male
Middle Aged
RNA, Small Cytoplasmic*
Ribonucleoproteins / isolation & purification
Salivary Glands / immunology*
Sjogren's Syndrome / immunology*
Submandibular Gland / cytology
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantigens; 0/RNA, Small Cytoplasmic; 0/Ribonucleoproteins; 0/SS-A antibodies; 0/SS-A antigen; 0/SS-B antibodies; 0/SS-B antigen; 0/TROVE2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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