Document Detail


Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model.
MedLine Citation:
PMID:  15787279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-proliferative effects of a novel bromomethoxylated arylphosphate derivative of zidovudine (compound DDE46, CAS 213982-96-8) were first examined in a zebra fish embryo model. DDE46 blocked the cell division at the 2-cell stage of the embryonic development followed by total cell fusion. DDE46 also inhibited the proliferation of the leukemic cell lines NALM-6 and MOLT-3. DDE46 enhanced the activity of the pro-apoptotic enzymes Caspase-3, Caspase-6, Caspase-8, and Caspase-9 leading to the apoptotic death of the leukemic cell line Jurkat. These results justify the further development of this agent as a new anti-leukemic drug candidate.
Authors:
Alexey O Benyumov; Taracad K Venkatachalam; Olga O Grigoriants; Alexei O Vassilev; Heather E Tibbles; Suzanne Downs; Darin Dumezb; Fatih M Uckun
Related Documents :
10706479 - Patterns of cell death induced by eluates from denture base acrylic resins in u-937 hum...
10761539 - Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human...
19368349 - Evaluation of antiproliferative activities and action mechanisms of extracts from two s...
15690129 - Inhibition of human neuroblastoma cell growth by cay10404, a highly selective cox-2 inh...
14719129 - Peyfp-nuc vector is a useful tool for three-dimensional and time-lapse observation of n...
9485079 - Apoptotic cell clearance in systemic lupus erythematosus. ii. role of beta2-glycoprotei...
20946259 - Cell cycle arrest induced by the bacterial adenylate cyclase toxins from bacillus anthr...
22367029 - Syntheses and cell-based phenotypic screen of novel 7-amino pyrido[2,3-d]pyrimidine-6-c...
19459049 - Neuronal cell biocompatibility and adhesion to modified cmos electrodes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  55     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-24     Completed Date:  2005-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  114-22     Citation Subset:  IM    
Affiliation:
Departments of Embryology, Parker Hughes Institute, Roseville, MN 55113, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology*,  therapeutic use
Apoptosis / drug effects
Caspases / antagonists & inhibitors
Cell Proliferation / drug effects
Dideoxynucleotides
Drug Screening Assays, Antitumor
Humans
Jurkat Cells
Leukemia / drug therapy*
Magnetic Resonance Spectroscopy
Nephelometry and Turbidimetry
Prodrugs / pharmacology
Tetrazolium Salts
Thiazoles
Thymidine Monophosphate / analogs & derivatives*,  pharmacology*
Tubulin / biosynthesis,  genetics
Zebrafish
Zidovudine / analogs & derivatives*,  pharmacology*
Chemical
Reg. No./Substance:
0/5-bromo-6-methoxy-5, 6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate; 0/Antineoplastic Agents; 0/Dideoxynucleotides; 0/Prodrugs; 0/Tetrazolium Salts; 0/Thiazoles; 0/Tubulin; 298-93-1/thiazolyl blue; 30516-87-1/Zidovudine; 365-07-1/Thymidine Monophosphate; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis and evaluation of the antibacterial and antitubercular activity of some N1-aral-N4-(3-chlo...
Next Document:  In vitro antifungal properties structure-activity relationships and studies on the mode of action of...