Document Detail


Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana.
MedLine Citation:
PMID:  22978209     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Inula aucheriana n-hexane, CHCl3 and MeOH extracts were evaluated for their anti-proliferative activity against HepG-2, MCF-7, MDBK and A-549 cells. The CHCl3 extract exhibited cytotoxic activity to the above cell lines with IC50 values of 13.5, 23.4, 10.5, and 26.9 microg/mL, respectively. The sesquiterpene lactone britannin was isolated from the above extract. This was further evaluated in the MTT assay to demonstrate strong cytotoxicity to the mentioned cell lines (IC50: 2.2, 5.9, 5.4, and 3.5 microg/mL, respectively), and the apoptotic inducing properties of britannin were evaluated on human breast adenocarcinoma (MCF-7) cells through the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay.
Authors:
Maryam Hamzeloo Moghadam; Homa Hajimehdipoor; Soodabeh Saeidnia; Azadeh Atoofi; Roxana Shahrestani; Roger W Read; Mahmoud Mosaddegh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  7     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  979-80     Citation Subset:  IM    
Affiliation:
Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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