Document Detail


Anti-progesterones: background and clinical physiology.
MedLine Citation:
PMID:  3069264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of anti-progesterones has provided a probe to examine the role of progesterone both in the normal cycle and in pregnancy. The most widely used of these agents, mifepristone, appears to act both directly at the endometrial progesterone receptor, and centrally by reducing circulating gonadotrophin concentrations. In addition, ovarian steroidogenesis may be modified. The clinical application of these agents for the interruption of pregnancy will be considered in the following chapters.
Authors:
I T Cameron; D L Healy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical obstetrics and gynaecology     Volume:  2     ISSN:  0950-3552     ISO Abbreviation:  Baillieres Clin Obstet Gynaecol     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-05-10     Completed Date:  1989-05-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8710782     Medline TA:  Baillieres Clin Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  597-607     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / therapeutic use*
Abortifacient Agents, Steroidal / pharmacokinetics,  pharmacology,  therapeutic use*
Animals
Estrenes / pharmacokinetics,  pharmacology,  therapeutic use*
Female
Humans
Macaca fascicularis
Mifepristone
Receptors, Progesterone / biosynthesis,  drug effects*,  genetics
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Steroidal; 0/Estrenes; 0/Receptors, Progesterone; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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