| Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. | |
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MedLine Citation:
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PMID: 9467439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe the clinical and laboratory findings in 10 patients with normal-pressure glaucoma and anti-Ro/SS-A positivity by enzyme-linked immunosorbent assay (ELISA) and to determine whether that positivity may be related to an autoimmune mechanism for the optic neuropathy. METHODS: In this prospective study, we evaluated ocular and systemic clinical findings of 10 patients with normal-pressure glaucoma and anti-Ro/SS-A positivity by ELISA, including sicca complex features. Oüchterlony immunodiffusion was performed to confirm the presence of antibodies for Ro/SS-A, and the presence of other serum antibodies and their possible cross-reactivities with Ro/SS-A were investigated. RESULTS: None of the 10 patients with normal-pressure glaucoma and anti-Ro/SS-A positivity (by ELISA) had clinical or laboratory signs of Sjögren syndrome or other connective tissue diseases. Only one of 10 patients had evidence of anti-Ro/SS-A antibodies by Oüchterlony immunodiffusion. All patients demonstrated serum immunoreactivity to bacterial heat shock protein 60 (hsp60) by Western blotting. Cross-reactivity between bacterial hsp60 and Ro/SS-A was demonstrated by Western blotting. Immunoreactivity to bacterial hsp60 by ELISA was significantly elevated in the sera of patients with normal-pressure glaucoma. Furthermore, patients with either normal-pressure or primary open-angle glaucoma had increased serum immunoreactivity to human hsp60. CONCLUSIONS: Anti-Ro/SS-A positivity by ELISA in 10 patients with normal-pressure glaucoma was associated with a high level of serum immunoreactivity to bacterial hsp60, which may indicate that their glaucomatous optic neuropathy involves an as yet unidentified autoimmune mechanism. The identification of autoantibodies that react with human hsp60 in patients with normal-pressure and primary open-angle glaucoma may signify a common finding associated with the glaucomatous optic neuropathy process in some patients and appears to be unrelated to intraocular pressure levels. |
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Authors:
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M B Wax; G Tezel; I Saito; R S Gupta; J B Harley; Z Li; C Romano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of ophthalmology Volume: 125 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-02-19 Completed Date: 1998-02-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-57 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA. wax@am.seer.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Autoantibodies / analysis* Autoantigens / immunology* Autoimmunity Blotting, Western Chaperonin 60 / immunology* Cross Reactions / immunology Enzyme-Linked Immunosorbent Assay Female Glaucoma, Open-Angle / immunology*, pathology Humans Immunodiffusion Intraocular Pressure* Male Middle Aged Optic Disk / pathology Optic Nerve Diseases / immunology Prospective Studies RNA, Small Cytoplasmic* Ribonucleoproteins / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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EY06810/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens; 0/Chaperonin 60; 0/RNA, Small Cytoplasmic; 0/Ribonucleoproteins; 0/SS-A antigen; 0/TROVE2 protein, human |
| Comments/Corrections | |
Comment In:
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Am J Ophthalmol. 1998 Feb;125(2):242-4
[PMID:
9467452
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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