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Anti-phospholipid antibodies are associated with response to interferon-beta1a treatment in MS: results from a 3-year longitudinal study.
MedLine Citation:
PMID:  22971466     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVES: To prospectively investigate the associations of baseline serum anti-phospholipid antibody (APLA) status on evolution of clinical and MRI measures in a multiple sclerosis (MS) patient cohort treated with interferon-beta (IFN-beta).
METHODS: Forty-seven relapsing-remitting (RR) MS patients, [26 APLA-positive (APLA(+)) and 21 APLA-negative (APLA(-))] matched for age, sex, disease duration, MRI characteristics, disability, and time on IFN-beta treatment, were enrolled. All patients were on intramuscular (IM) IFN-beta1a for at least 3 years and remained on the same treatment over the 3-year duration of the study.
RESULTS: The APLA(+) group accumulated significantly higher T2-LV over the 3-year follow-up than the APLA(-) group (+31% versus -1·1%, P = 0·043). The MTR of T1-LV (-3·3% versus +4·7%, P = 0·04) in the APLA(+) group was lower compared to the APLA(-) group. At 3-year follow-up, the APLA(+) group had increased tissue damage as measured by diffusion entropy (+4% versus -2·5%, P = 0·019) and whole brain volume loss (-0·69% versus -0·37%, P = 0·041), compared to the APLA(-) group. There were more clinical relapses in the MS APLA(+) group compared to APLA(-) patients (18 versus 10) and a higher frequency of sustained disability progression (7/26 or 27% versus 2/21 or 9·5%).
CONCLUSIONS: This study suggests that APLA(+) RRMS patients treated with IFN-beta1a develop more severe MRI and clinical deterioration. Future studies are required to evaluate the role of APLA as potential biomarkers for disease prognosis versus predictors for therapeutic response to IFN-beta therapy.
Authors:
Robert Zivadinov; Murali Ramanathan; Julian Ambrus; Sara Hussein; Deepa P Ramasamy; Michael G Dwyer; Niels Bergsland; Alireza Minagar; Bianca Weinstock-Guttman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  34     ISSN:  1743-1328     ISO Abbreviation:  Neurol. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  761-9     Citation Subset:  IM    
Affiliation:
State University of New York, USA.
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