| Anti-phospholipid antibodies are associated with response to interferon-beta1a treatment in MS: results from a 3-year longitudinal study. | |
| | |
MedLine Citation:
|
PMID: 22971466 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVES: To prospectively investigate the associations of baseline serum anti-phospholipid antibody (APLA) status on evolution of clinical and MRI measures in a multiple sclerosis (MS) patient cohort treated with interferon-beta (IFN-beta). METHODS: Forty-seven relapsing-remitting (RR) MS patients, [26 APLA-positive (APLA(+)) and 21 APLA-negative (APLA(-))] matched for age, sex, disease duration, MRI characteristics, disability, and time on IFN-beta treatment, were enrolled. All patients were on intramuscular (IM) IFN-beta1a for at least 3 years and remained on the same treatment over the 3-year duration of the study. RESULTS: The APLA(+) group accumulated significantly higher T2-LV over the 3-year follow-up than the APLA(-) group (+31% versus -1·1%, P = 0·043). The MTR of T1-LV (-3·3% versus +4·7%, P = 0·04) in the APLA(+) group was lower compared to the APLA(-) group. At 3-year follow-up, the APLA(+) group had increased tissue damage as measured by diffusion entropy (+4% versus -2·5%, P = 0·019) and whole brain volume loss (-0·69% versus -0·37%, P = 0·041), compared to the APLA(-) group. There were more clinical relapses in the MS APLA(+) group compared to APLA(-) patients (18 versus 10) and a higher frequency of sustained disability progression (7/26 or 27% versus 2/21 or 9·5%). CONCLUSIONS: This study suggests that APLA(+) RRMS patients treated with IFN-beta1a develop more severe MRI and clinical deterioration. Future studies are required to evaluate the role of APLA as potential biomarkers for disease prognosis versus predictors for therapeutic response to IFN-beta therapy. |
| | |
Authors:
|
Robert Zivadinov; Murali Ramanathan; Julian Ambrus; Sara Hussein; Deepa P Ramasamy; Michael G Dwyer; Niels Bergsland; Alireza Minagar; Bianca Weinstock-Guttman |
Related Documents
:
|
17702796 - Ranking dental aesthetics and thresholds of treatment need: a comparison between patien... 20226576 - Comparison of perioperative morbidity after lefort iii and monobloc distraction osteoge... 12905436 - A clinical evaluation of dry socket in a nigerian teaching hospital. 10833006 - Treatment of mandibular asymmetry by distraction osteogenesis and orthodontics: a repor... 2846216 - The natural history of facial paralysis in herpes zoster. 16778696 - Natural course of disc morphology in patients with sciatica: an mri study using a stand... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurological research Volume: 34 ISSN: 1743-1328 ISO Abbreviation: Neurol. Res. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
|
Languages: eng Pagination: 761-9 Citation Subset: IM |
Affiliation:
|
State University of New York, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Arterial, venous and other vascular risk factors in multiple sclerosis.
Next Document: CCSVI is associated with multiple sclerosis.