| Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids. | |
| | |
MedLine Citation:
|
PMID: 19460115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Animal studies suggest that increased consumption of the long-chain omega-3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, can protect against the development of obesity in animals exposed to an obesogenic diet and reduce body fat when already obese. There is also evidence that increased intakes of these fatty acids can reduce body fat in humans, but human studies are relatively few and have generally been conducted over short time periods with small sample sizes, making it difficult to draw definitive conclusions. Reported reductions in body fat may result from appetite-suppressing effects, adipocyte apoptosis and changes of gene expression in skeletal muscle, heart, liver, intestine and adipose tissues that suppress fat deposition and increase fat oxidation and energy expenditure. We conclude that increased intakes of long-chain omega-3 fatty acids may improve body composition, but longer-term human studies are needed to confirm efficacy and determine whether increasing omega-3 intakes might be an effective strategy to combat obesity. |
| | |
Authors:
|
J D Buckley; P R C Howe |
Related Documents
:
|
9076665 - Polyunsaturated fatty acids increase the sensitivity of 36b10 rat astrocytoma cells to ... 20833075 - Marine n-3 polyunsaturated fatty acids in patients with end-stage renal failure and i... 15784975 - Lipid peroxidation of a human hepatoma cell line (hepg2) after incorporation of linolei... 19904605 - Fatty acid composition of frontal, temporal and parietal neocortex in the normal human ... 20824345 - Pathophysiology of fatty acid oxidation disorders. 9864455 - Structure of sulfated o-specific polysaccharide of the marine bacterium pseudoalteromon... |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-05-12 |
Journal Detail:
|
Title: Obesity reviews : an official journal of the International Association for the Study of Obesity Volume: 10 ISSN: 1467-789X ISO Abbreviation: Obes Rev Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-11-05 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100897395 Medline TA: Obes Rev Country: England |
Other Details:
|
Languages: eng Pagination: 648-59 Citation Subset: IM |
Affiliation:
|
Nutritional Physiology Research Centre and Australian Technology Network (ATN) Centre for Metabolic Fitness, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia. jon.buckley@unisa.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
drug effects*,
metabolism* Animals Apoptosis / drug effects Body Composition / drug effects Diet, Reducing Disease Models, Animal Energy Metabolism / drug effects Evidence-Based Medicine Fatty Acids, Omega-3 / administration & dosage*, pharmacology Humans Obesity / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Paediatric obesity, physical activity and the musculoskeletal system.
Next Document: Discontinuation due to adverse events in randomized trials of orlistat, sibutramine and rimonabant: ...