Document Detail

Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids.
MedLine Citation:
PMID:  19460115     Owner:  NLM     Status:  MEDLINE    
Animal studies suggest that increased consumption of the long-chain omega-3 polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid, can protect against the development of obesity in animals exposed to an obesogenic diet and reduce body fat when already obese. There is also evidence that increased intakes of these fatty acids can reduce body fat in humans, but human studies are relatively few and have generally been conducted over short time periods with small sample sizes, making it difficult to draw definitive conclusions. Reported reductions in body fat may result from appetite-suppressing effects, adipocyte apoptosis and changes of gene expression in skeletal muscle, heart, liver, intestine and adipose tissues that suppress fat deposition and increase fat oxidation and energy expenditure. We conclude that increased intakes of long-chain omega-3 fatty acids may improve body composition, but longer-term human studies are needed to confirm efficacy and determine whether increasing omega-3 intakes might be an effective strategy to combat obesity.
J D Buckley; P R C Howe
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-05-12
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  10     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  648-59     Citation Subset:  IM    
Nutritional Physiology Research Centre and Australian Technology Network (ATN) Centre for Metabolic Fitness, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
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MeSH Terms
Adipose Tissue / drug effects*,  metabolism*
Apoptosis / drug effects
Body Composition / drug effects
Diet, Reducing
Disease Models, Animal
Energy Metabolism / drug effects
Evidence-Based Medicine
Fatty Acids, Omega-3 / administration & dosage*,  pharmacology
Obesity / prevention & control*
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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