| Anti-obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes. | |
| | |
MedLine Citation:
|
PMID: 22278718 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: We examined the anti-obesity effect of fermented Curcuma longa L. (turmeric) standardised ethanol extract (FTE) in the C57BL/6J ob/ob mouse model. Mice were fed a chow diet containing FTE (0, 200, or 500 mg kg(-1) body weight) for 9 weeks. RESULTS: Supplementation with FTE significantly reduced body weight gain and retroperitoneal and epididymal adipose tissue weights compared to the ob/ob control group. Additionally, total cholesterol and triglyceride levels in serum and liver were significantly decreased in FTE-200 and FTE-500 groups when compared to those of the ob/ob control group, whereas the high-density lipoprotein-cholesterol level was significantly increased. The levels of serum adiponectin as well as mRNA expression of lipases, such as hormone sensitive lipase and adipose triglyceride lipase, were clearly increased. In primary adipocytes of C57BL/6J mice, FTE treatment caused a significant increase glycerol release and hormone sensitive lipase levels and decreased perilipin A levels. CONCLUSION: These results suggest that supplementation of FTE has potent anti-obesity effects by controlling body weight, fat mass, serum lipids, and hepatic lipids. Moreover, FTE could be considered a potential resource for the treatment of obesity through its promotion of lipolysis via the protein kinase A pathway. Copyright © 2012 Society of Chemical Industry. |
| | |
Authors:
|
Jin-Nyoung Ho; Ja Young Jang; Ho-Geun Yoon; Yongjae Kim; Sunoh Kim; Woojin Jun; Jeongmin Lee |
Related Documents
:
|
21504968 - Alteration of negatively charged residues in the 89 to 99 domain of apoa-i affects lipi... 15545348 - Evaluating metabolic syndrome in a medical physiology laboratory. 21226578 - Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. 8419118 - Suppression of glut4 expression in skeletal muscle of rats that are obese from high fat... 17033308 - Cholesterol gallstones. 21722398 - Effects of two lactobacillus strains on lipid metabolism and intestinal microflora in r... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
|
Title: Journal of the science of food and agriculture Volume: - ISSN: 1097-0010 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376334 Medline TA: J Sci Food Agric Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Society of Chemical Industry. |
Affiliation:
|
Department of Medical Nutrition, Kyung Hee University, Yongin 446-701, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multidimensional fluorescence studies of the phenolic content of dissolved organic carbon in humic s...
Next Document: Changing the treatment goal at the end of life: effects of a guideline at a hospital.