Document Detail


Anti-obesity activity of Allium fistulosum L. extract by down-regulation of the expression of lipogenic genes in high-fat diet-induced obese mice.
MedLine Citation:
PMID:  21468588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the anti-obesity activity and underlying mechanism of a 70% ethanol extract from Allium fistulosum L. (AFE) in high-fat diet-induced obese mice. AFE was orally administered to mice with the high-fat diet at a dose of 400 mg/kg/day for 6.5 weeks. AFE treatment significantly reduced body weight and white adipose tissue (subcutaneous, epididymal and retroperitoneal) weight as well as adipocyte size compared to high-fat diet-induced control mice. AFE also significantly decreased triglyceride, total cholesterol, low density lipoprotein-cholesterol and leptin concentrations in the serum of the mice, whereas it increased adiponectin levels. Furthermore, AFE suppressed the mRNA expression of transcription factors, such as sterol regulatory element binding protein-1c and peroxisome proliferator activated receptor γ, as well as fatty acid synthase in the subcutaneous adipose tissue. These results suggest that AFE inhibited the adipose size, fat accumulation and serum lipid concentrations by down-regulation of the expression of genes involved in lipogenesis in the adipose tissue of high-fat diet-induced obese mice.
Authors:
Yoon-Young Sung; Taesook Yoon; Seung Ju Kim; Won-Kyung Yang; Ho Kyoung Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-10
Journal Detail:
Title:  Molecular medicine reports     Volume:  4     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-04-06     Completed Date:  2011-07-13     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
Affiliation:
Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood
Adipose Tissue, White / drug effects,  pathology
Allium / chemistry*
Animals
Anti-Obesity Agents / pharmacology*
Body Weight / drug effects
Dietary Fats / administration & dosage*,  pharmacology*
Down-Regulation / drug effects*,  genetics
Feeding Behavior / drug effects
Leptin / blood
Lipids / blood
Lipogenesis / drug effects,  genetics*
Mice
Mice, Inbred C57BL
Mice, Obese
Phytotherapy
Plant Extracts / pharmacology*
RNA, Messenger / genetics,  metabolism
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Anti-Obesity Agents; 0/Dietary Fats; 0/Leptin; 0/Lipids; 0/Plant Extracts; 0/RNA, Messenger

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