Document Detail

Anti-obesity effect of Pinellia ternata extract in Zucker rats.
MedLine Citation:
PMID:  16755034     Owner:  NLM     Status:  MEDLINE    
Pinellia ternata is known as the herb effective in removing dampness-phlegm, one of the causes of obesity in traditional Korean medicine. Pinellia ternata water extract (PE) was fed to rats after mixing with diet once a day (400 mg x kg(-1)) for 6 weeks. We investigated its effect on the thermogenesis and fatty acids oxidation with obese Zucker rats. We also determined the gene expression of uncoupling protein 1 (UCP1), peroxisome proliferators-activated receptor alpha (PPARalpha), and PPARgamma coactivator 1alpha (PGC1alpha). The PE treatment lowered the levels of triglyceride and free fatty acids (p<0.05) in blood of the obese rats and the body weight was also reduced slightly. It was also observed that PE significantly increased the expression of both UCP1 mRNA in brown adipose tissue (BAT) (p<0.001) and PPARalpha and PGC1alpha mRNA in white visceral adipose tissue (WAT) (p<0.05 and p<0.001, respectively), which may cause a reduction of obesity. These results suggested that PE would be able to affect anti-obesity through thermogenesis and fatty acid oxidation.
Yoo-Jeong Kim; Young-Oh Shin; Young-Wan Ha; Sanghyun Lee; Jae-Keun Oh; Yeong Shik Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  29     ISSN:  1347-5215     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-06     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1278-81     Citation Subset:  IM    
Natural Products Research Institute and College of Pharmacy, Seoul National University, Jongno-gu, Seoul, Korea.
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MeSH Terms
Anti-Obesity Agents / isolation & purification,  pharmacology,  therapeutic use*
Body Weight / drug effects
Fatty Acids / blood,  metabolism
Gene Expression / drug effects
Ion Channels / genetics
Medicine, Korean Traditional
Mitochondrial Proteins / genetics
Obesity / blood,  drug therapy*,  genetics,  metabolism
PPAR alpha / genetics
Pinellia / chemistry*
Plant Extracts / isolation & purification,  pharmacology,  therapeutic use*
RNA-Binding Proteins / genetics
Rats, Zucker
Thermogenesis / drug effects
Transcription Factors / genetics
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Fatty Acids; 0/Ion Channels; 0/Mitochondrial Proteins; 0/PPAR alpha; 0/Plant Extracts; 0/Ppargc1a protein, rat; 0/RNA-Binding Proteins; 0/Transcription Factors; 0/mitochondrial uncoupling protein

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