| Anti-neutrophil cytoplasmic antibodies (ANCA) in serum and bronchoalveolar lavage fluids of cystic fibrosis patients and patients with idiopathic bronchiectasis. | |
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MedLine Citation:
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PMID: 21043377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in the serum and bronchoalveolar lavage fluid (BALF) of 21 cystic fibrosis (CF), 7 idiopathic bronchiectasis (IBR), and 11 control children and the relation between ANCA and any bacteria grown in BALF. Six of the CFs, but none of the IBRs or controls had positive serum cytoplasmic or perinuclear-ANCA (c-ANCA, p-ANCA). Serum autoantibodies against bactericidal/permeability increasing protein (BPI-ANCA) were positive in 2 CFs, 1 IBR and 1 control. While none of the CFs, IBRs or controls had positive BALF (c- or p-ANCA), 1 CF, 1 IBR and none of the controls had positive BALF BPI-ANCA. Pseudomonas aeruginosa was not grown in the specimens of any of the subjects. As the number of the patients in our study was very limited, further longitudinal and well-designed studies are necessary to show whether or not the presence of ANCA in serum or BALF relates to the presence of P. aeruginosa infection in the airways of CF and IBR patients. |
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Authors:
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Nazan Cobanoğlu; Uğur Ozcelik; Ilker Cetin; Ebru Yalçin; Deniz Doğru; Nural Kiper; Ayşin Bakkaloğlu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Turkish journal of pediatrics Volume: 52 ISSN: 0041-4301 ISO Abbreviation: Turk. J. Pediatr. Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417505 Medline TA: Turk J Pediatr Country: Turkey |
Other Details:
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Languages: eng Pagination: 343-7 Citation Subset: IM |
Affiliation:
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Unit of Pediatric Pulmonary Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antibodies, Antineutrophil Cytoplasmic / blood, immunology* Bronchiectasis / immunology, metabolism*, microbiology Bronchoalveolar Lavage Fluid / chemistry* Bronchoscopy Child Child, Preschool Cross-Sectional Studies Cystic Fibrosis / immunology, metabolism*, microbiology Enzyme-Linked Immunosorbent Assay Female Humans Male Pseudomonas Infections / immunology Pseudomonas aeruginosa / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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