Document Detail


Anti-neutrophil cytoplasmic antibodies (ANCA) in serum and bronchoalveolar lavage fluids of cystic fibrosis patients and patients with idiopathic bronchiectasis.
MedLine Citation:
PMID:  21043377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the presence of anti-neutrophil cytoplasmic antibodies (ANCA) in the serum and bronchoalveolar lavage fluid (BALF) of 21 cystic fibrosis (CF), 7 idiopathic bronchiectasis (IBR), and 11 control children and the relation between ANCA and any bacteria grown in BALF. Six of the CFs, but none of the IBRs or controls had positive serum cytoplasmic or perinuclear-ANCA (c-ANCA, p-ANCA). Serum autoantibodies against bactericidal/permeability increasing protein (BPI-ANCA) were positive in 2 CFs, 1 IBR and 1 control. While none of the CFs, IBRs or controls had positive BALF (c- or p-ANCA), 1 CF, 1 IBR and none of the controls had positive BALF BPI-ANCA. Pseudomonas aeruginosa was not grown in the specimens of any of the subjects. As the number of the patients in our study was very limited, further longitudinal and well-designed studies are necessary to show whether or not the presence of ANCA in serum or BALF relates to the presence of P. aeruginosa infection in the airways of CF and IBR patients.
Authors:
Nazan Cobanoğlu; Uğur Ozcelik; Ilker Cetin; Ebru Yalçin; Deniz Doğru; Nural Kiper; Ayşin Bakkaloğlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  52     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Affiliation:
Unit of Pediatric Pulmonary Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Antineutrophil Cytoplasmic / blood,  immunology*
Bronchiectasis / immunology,  metabolism*,  microbiology
Bronchoalveolar Lavage Fluid / chemistry*
Bronchoscopy
Child
Child, Preschool
Cross-Sectional Studies
Cystic Fibrosis / immunology,  metabolism*,  microbiology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Pseudomonas Infections / immunology
Pseudomonas aeruginosa / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic

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