Document Detail

Anti-myelin basic protein T cells protect hippocampal neurons against trimethyltin-induced damage.
MedLine Citation:
PMID:  17496797     Owner:  NLM     Status:  MEDLINE    
We investigated the influence of administration of autoimmune T cells on trimethyltin-induced degeneration of hippocampal neurons. Female Lewis rats received 8 mg/kg trimethyltin intraperitoneally alone, or followed 24 h later by a second intravenous injection of anti-myelin basic protein T cells (green fluorescent protein-tagged). Neurodegeneration was assessed by NeuN and Nissl cell counts 21 days after trimethyltin injection. We found that neurodegeneration in the CA4 region of the hippocampus was significantly reduced in the group receiving T cells. T cells also caused an augmentation of trimethyltin-induced hippocampal astrocytic activation and astrocytic TrkA expression, which was particularly intense in the CA4 region. Our study provides the first evidence of neuroprotection evoked by transferred T cells following a neurotoxic brain insult. The data suggest that mediation of the neuroprotective effects of T-cell-released nerve growth factor occurs mainly via hippocampal astroglial TrkA receptors.
Iwona Kurkowska-Jastrzebska; Ilona Joniec; Malgorzata Zaremba; Anna Fiedorowicz; Anna Czlonkowska; Barbara Oderfeld-Nowak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  18     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-06-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
2nd Department of Neurology, Institute of Psychiatry and Neurology, Laboratory of Mechanisms of Neurodegeneration and Neuroprotection, Medical University, Warsaw, Poland.
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MeSH Terms
Cell Count
Glial Fibrillary Acidic Protein / metabolism
Hippocampus / pathology*
Myelin Basic Proteins / immunology*
Nerve Degeneration* / chemically induced,  pathology,  therapy
Neurons / drug effects,  metabolism*
Phosphopyruvate Hydratase / metabolism
Rats, Inbred Lew
Receptor, trkA / metabolism
T-Lymphocytes / cytology,  immunology,  metabolism*
Trimethyltin Compounds*
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/Myelin Basic Proteins; 0/Trimethyltin Compounds; 1631-73-8/trimethyltin; EC, trkA; EC Hydratase

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