Document Detail

Anti-mutagenic chalcones: antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium.
MedLine Citation:
PMID:  6303339     Owner:  NLM     Status:  MEDLINE    
Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.
T Torigoe; M Arisawa; S Itoh; M Fujiu; H B Maruyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  112     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  833-42     Citation Subset:  IM    
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MeSH Terms
Benzopyrenes / antagonists & inhibitors*
Chalcone / analogs & derivatives,  pharmacology*
Mutagenicity Tests
Mutagens / antagonists & inhibitors*
Propiophenones / pharmacology*
Salmonella typhimurium / genetics
Structure-Activity Relationship
Reg. No./Substance:
0/Benzopyrenes; 0/Mutagens; 0/Propiophenones; 50-32-8/Benzo(a)pyrene; 94-41-7/Chalcone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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