Document Detail


Anti-lipid peroxidation and induction of apoptosis in the erythroleukaemic cell line K562 by extracts from (Tunisian) Rhamnus alaternus L. (Rhamnaceae).
MedLine Citation:
PMID:  21726127     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Total oligomer flavonoids (TOF) enriched and ethyl acetate (EA) extracts from Rhamnus alaternus induce apoptotic death in human chronic myelogenous leukaemia K562 cell line, as demonstrated by gel electrophoresis, which demonstrates the characteristic ladder patterns of DNA fragmentation and the proteolytic cleavage of poly(ADP ribose) polymerase (PARP). The effect of R. alaternus extract in reducing oxidative stress was evaluated by anti-lipid peroxidation which was monitored by measuring malondialdehyde level in K562 cultured cells. The TOF and EA extracts were found to be effective to protect against lipid peroxidation. Their IC(50) values were 196 and 273 µg mL(-1), respectively. These findings suggest that R. alaternus extracts exhibit potential antioxidant and proapoptotic properties.
Authors:
Rebai Ben Ammar; Aicha Neffati; Ines Skandrani; Mohamed Ben Sghaier; Wissem Bhouri; Kamel Ghedira; Leila Chekir-Ghedira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Natural product research     Volume:  25     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1047-58     Citation Subset:  IM    
Affiliation:
a Unité de Pharmacognosie/Biologie Moléculaire 99/UR/07-03, Faculté de Pharmacie de Monastir , Rue Avicenne , 5019 Monastir , Tunisie.
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