| Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC. | |
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MedLine Citation:
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PMID: 19679456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The methanolic extract of Dillenia indica L. fruits showed significant anti-leukemic activity in human leukemic cell lines U937, HL60 and K562. This finding led to fractionation of the methanolic extract, on the basis of polarity, in which the ethyl acetate fraction showed the highest anti-leukemic activity. A major compound, betulinic acid, was isolated from the ethyl acetate fraction by silica gel column chromatography and was identified and characterized. Betulinic acid could explain the anti-leukemic activity of the methanolic extract and the ethyl acetate fraction. Hence the quantitative estimation of betulinic acid was approached in methanolic extract and fractions using HPLC. |
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Authors:
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Deepak Kumar; Sumana Mallick; Joseph R Vedasiromoni; Bikas C Pal |
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Publication Detail:
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Type: Journal Article Date: 2009-08-12 |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 17 ISSN: 1618-095X ISO Abbreviation: Phytomedicine Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 431-5 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier GmbH. All rights reserved. |
Affiliation:
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National Institute of Pharmaceutical Education and Research, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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isolation & purification,
pharmacology,
therapeutic use* Cell Line, Tumor Chromatography, High Pressure Liquid Dilleniaceae / chemistry* Fruit HL-60 Cells Humans Leukemia / drug therapy* Phytotherapy* Plant Extracts / chemistry, pharmacology, therapeutic use* Triterpenes / isolation & purification, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/Triterpenes; 472-15-1/betulinic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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