Document Detail

Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC.
MedLine Citation:
PMID:  19679456     Owner:  NLM     Status:  MEDLINE    
The methanolic extract of Dillenia indica L. fruits showed significant anti-leukemic activity in human leukemic cell lines U937, HL60 and K562. This finding led to fractionation of the methanolic extract, on the basis of polarity, in which the ethyl acetate fraction showed the highest anti-leukemic activity. A major compound, betulinic acid, was isolated from the ethyl acetate fraction by silica gel column chromatography and was identified and characterized. Betulinic acid could explain the anti-leukemic activity of the methanolic extract and the ethyl acetate fraction. Hence the quantitative estimation of betulinic acid was approached in methanolic extract and fractions using HPLC.
Deepak Kumar; Sumana Mallick; Joseph R Vedasiromoni; Bikas C Pal
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Publication Detail:
Type:  Journal Article     Date:  2009-08-12
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  17     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier GmbH. All rights reserved.
National Institute of Pharmaceutical Education and Research, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India.
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MeSH Terms
Antineoplastic Agents, Phytogenic / isolation & purification,  pharmacology,  therapeutic use*
Cell Line, Tumor
Chromatography, High Pressure Liquid
Dilleniaceae / chemistry*
HL-60 Cells
Leukemia / drug therapy*
Plant Extracts / chemistry,  pharmacology,  therapeutic use*
Triterpenes / isolation & purification,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/Triterpenes; 472-15-1/betulinic acid

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