Document Detail


Anti-leukemic activities of Dictyostelium secondary metabolites: a novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells.
MedLine Citation:
PMID:  17027864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has previously been shown that DIF-1, a differentiation-inducing factor of the cellular slime mold Dictyostelium discoideum, possesses antitumor activities in mammalian tumor cells and that neuronal differentiation of PC12 cells can be induced with furanodictines (FDs), aminosugar analogs found in D. discoideum, or dictyoglucosamines (DGs), N-acetyl glucosamine derivatives (DG-A from D. purpureum and DG-B from D. discoideum). Thus, cellular slime molds are attractive natural resources that may provide valuable lead compounds to be utilized in the field of pharmacology and medicine. In this study, we have isolated a novel aromatic compound, 4-methyl-5-n-pentylbenzene-1,3-diol (MPBD), from fruiting bodies of the cellular slime mold D. mucoroides and assessed the in vitro antiproliferative activities of MPBD, FDs, and DGs in human leukemia K562 and HL-60 cells. MPBD at 20-80 microM dose-dependently suppressed cell growth in both K562 and HL-60 cells. While FDs at 10-80 microM did not affect cell growth, DGs at 10-40 microM dose-dependently suppressed cell growth in the cells. Although we failed to find the roles of FDs and DGs in the original organisms, MPBD at 5-20 microM was found to promote stalk cell formation in D. discoideum. The present results indicate that MPBD, DGs or their derivatives may have therapeutic potential in the treatment of cancer and confirm our expectations regarding cellular slime molds as drug resources.
Authors:
Haruhisa Kikuchi; Yoshiteru Oshima; Aya Ichimura; Naomi Gokan; Aiko Hasegawa; Kohei Hosaka; Yuzuru Kubohara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-06
Journal Detail:
Title:  Life sciences     Volume:  80     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Affiliation:
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemistry,  isolation & purification,  pharmacology*
Cell Proliferation / drug effects*
Dictyostelium / growth & development,  metabolism*
Dose-Response Relationship, Drug
HL-60 Cells
Hexanones / metabolism
Humans
K562 Cells
Leukemia / drug therapy*
Molecular Structure
Resorcinols / chemistry,  isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/4-methyl-5-pentylbenzene-1,3-diol; 0/Antineoplastic Agents; 0/Hexanones; 0/Resorcinols; 111050-72-7/1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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