Document Detail

Anti-A isoagglutinin as a risk factor for the development of pure red cell aplasia after major ABO-incompatible allogeneic bone marrow transplantation.
MedLine Citation:
PMID:  10673677     Owner:  NLM     Status:  MEDLINE    
Delayed erythropoiesis and pure red cell aplasia (PRCA) have been reported after major ABO-incompatible BMT. We attempted to find risk factors for the development of PRCA in 27 patients who underwent major ABO-incompatible BMT. In all patients, the donor marrow was depleted of RBCs before infusion. In 22 patients, isoagglutinins were determined until they disappeared. In eight (29.6%) out of 27 patients, bone marrow examination following BMT showed the findings of PRCA. We analyzed various clinico-pathologic risk factors and isoagglutinin type was the only significant risk factor. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than patients with anti-B (8/17 vs 0/9). Median days to the disappearance of isoagglutinins tended to be longer in patients with PRCA (PRCA vsnon-PRCA, 200 vs 66 days) and in cases with anti-A isoagglutinins (anti-A vsanti-B, 160 vs 51 days). Times to disappearance of isoagglutinins correlated with times to reticulocytes over 1% and initial appearance of donor type RBC (R2 = 0.708 and 0.711). In conclusion, RBC engraftment following major ABO-incompatible BMT was dependent on the disappearance of isoagglutinins against donor RBC, and anti-A isoagglutinin was a risk factor for the development of PRCA after major ABO-incompatible allogeneic BMT. Bone Marrow Transplantation (2000) 25, 179-184.
J H Lee; K H Lee; S Kim; J S Lee; S H Kim; S W Kwon; W K Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  25     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-20     Completed Date:  2000-03-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Division of Oncology-Hematology, Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
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MeSH Terms
ABO Blood-Group System / immunology*
Antigen-Antibody Complex / adverse effects,  immunology
Blood Group Incompatibility / blood,  immunology*
Bone Marrow Transplantation / adverse effects*,  immunology
Graft Survival
Graft vs Host Disease
Immunoglobulin Isotypes / immunology
Isoantibodies / blood*
Middle Aged
Red-Cell Aplasia, Pure / blood,  etiology*,  immunology
Risk Factors
Time Factors
Treatment Outcome
Reg. No./Substance:
0/ABO Blood-Group System; 0/Antigen-Antibody Complex; 0/Immunoglobulin Isotypes; 0/Isoantibodies

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