| Anti-A isoagglutinin as a risk factor for the development of pure red cell aplasia after major ABO-incompatible allogeneic bone marrow transplantation. | |
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MedLine Citation:
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PMID: 10673677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Delayed erythropoiesis and pure red cell aplasia (PRCA) have been reported after major ABO-incompatible BMT. We attempted to find risk factors for the development of PRCA in 27 patients who underwent major ABO-incompatible BMT. In all patients, the donor marrow was depleted of RBCs before infusion. In 22 patients, isoagglutinins were determined until they disappeared. In eight (29.6%) out of 27 patients, bone marrow examination following BMT showed the findings of PRCA. We analyzed various clinico-pathologic risk factors and isoagglutinin type was the only significant risk factor. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than patients with anti-B (8/17 vs 0/9). Median days to the disappearance of isoagglutinins tended to be longer in patients with PRCA (PRCA vsnon-PRCA, 200 vs 66 days) and in cases with anti-A isoagglutinins (anti-A vsanti-B, 160 vs 51 days). Times to disappearance of isoagglutinins correlated with times to reticulocytes over 1% and initial appearance of donor type RBC (R2 = 0.708 and 0.711). In conclusion, RBC engraftment following major ABO-incompatible BMT was dependent on the disappearance of isoagglutinins against donor RBC, and anti-A isoagglutinin was a risk factor for the development of PRCA after major ABO-incompatible allogeneic BMT. Bone Marrow Transplantation (2000) 25, 179-184. |
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Authors:
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J H Lee; K H Lee; S Kim; J S Lee; S H Kim; S W Kwon; W K Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bone marrow transplantation Volume: 25 ISSN: 0268-3369 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-20 Completed Date: 2000-03-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: IM |
Affiliation:
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Division of Oncology-Hematology, Department of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System
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immunology* Adult Antigen-Antibody Complex / adverse effects, immunology Blood Group Incompatibility / blood, immunology* Bone Marrow Transplantation / adverse effects*, immunology Female Graft Survival Graft vs Host Disease Humans Immunoglobulin Isotypes / immunology Isoantibodies / blood* Male Middle Aged Red-Cell Aplasia, Pure / blood, etiology*, immunology Risk Factors Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System; 0/Antigen-Antibody Complex; 0/Immunoglobulin Isotypes; 0/Isoantibodies |
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