| Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease. | |
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MedLine Citation:
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PMID: 11207999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A high concentration of interleukin (IL)-8 has been observed in the tracheobronchial aspirate of infants with chronic lung disease (CLD), although the pattern varies depending on the type of CLD. Alveolar fluid from patients with adult respiratory distress syndrome (ARDS) also contains an elevated level of IL-8. Recently, the presence of anti-IL-8 autoantibody was demonstrated in the alveolar fluid from patients with ARDS. METHODS AND RESULTS: The concentration of anti-IL-8 autoantibody in the tracheobronchial aspirate of infants with CLD was measured in order to discover whether there was any correlation with the concentration of IL-8. Similar to IL-8 concentration, the anti-IL-8 IgM antibody concentration in all infants with CLD following intrauterine infection was already high during the first 48 h. However, the concentration in infants with CLD following respiratory distress syndrome began to increase after 11 days of life, in contrast with the rise in IL-8 between 48 h after birth and day 5. CONCLUSIONS: The presence of anti-IL-8 autoantibody may provide a mechanism that limits the bioavailability of free IL-8 in the lungs. In addition, the time lag between the increase in IL-8 and anti-IL-8 IgM autoantibody demonstrated in the present study could be used to estimate the time when the inflammation begins, even if the IL-8 concentration is already high. |
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Authors:
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J Takasaki; Y Ogawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 43 ISSN: 1328-8067 ISO Abbreviation: Pediatr Int Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-05-10 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
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Languages: eng Pagination: 48-52 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan. fwkd2376@mb.infoweb.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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analysis* Bronchoalveolar Lavage Fluid / chemistry, immunology* Chronic Disease Humans Immunoglobulin M / analysis Infant Infant, Newborn Interleukin-8 / immunology* Lung Diseases / etiology, immunology* Respiratory Distress Syndrome, Newborn / complications |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulin M; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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