Document Detail

Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease.
MedLine Citation:
PMID:  11207999     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A high concentration of interleukin (IL)-8 has been observed in the tracheobronchial aspirate of infants with chronic lung disease (CLD), although the pattern varies depending on the type of CLD. Alveolar fluid from patients with adult respiratory distress syndrome (ARDS) also contains an elevated level of IL-8. Recently, the presence of anti-IL-8 autoantibody was demonstrated in the alveolar fluid from patients with ARDS. METHODS AND RESULTS: The concentration of anti-IL-8 autoantibody in the tracheobronchial aspirate of infants with CLD was measured in order to discover whether there was any correlation with the concentration of IL-8. Similar to IL-8 concentration, the anti-IL-8 IgM antibody concentration in all infants with CLD following intrauterine infection was already high during the first 48 h. However, the concentration in infants with CLD following respiratory distress syndrome began to increase after 11 days of life, in contrast with the rise in IL-8 between 48 h after birth and day 5. CONCLUSIONS: The presence of anti-IL-8 autoantibody may provide a mechanism that limits the bioavailability of free IL-8 in the lungs. In addition, the time lag between the increase in IL-8 and anti-IL-8 IgM autoantibody demonstrated in the present study could be used to estimate the time when the inflammation begins, even if the IL-8 concentration is already high.
J Takasaki; Y Ogawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  43     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-10     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  48-52     Citation Subset:  IM    
Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan.
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MeSH Terms
Autoantibodies / analysis*
Bronchoalveolar Lavage Fluid / chemistry,  immunology*
Chronic Disease
Immunoglobulin M / analysis
Infant, Newborn
Interleukin-8 / immunology*
Lung Diseases / etiology,  immunology*
Respiratory Distress Syndrome, Newborn / complications
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin M; 0/Interleukin-8

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