| Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-{kappa}B signaling in resident macrophages. | |
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MedLine Citation:
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PMID: 21551236 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Human mesenchymal stem/progenitor cells (hMSCs) repair tissues and modulate immune systems but the mechanisms are not fully understood. Here we demonstrated that hMSCs are activated by inflammatory signals to secrete the anti-inflammatory protein, TSG-6 and thereby create a negative feedback loop that reduces inflammation in zymosan-induced peritonitis. The results demonstrate for the first time that TSG-6 interacts through the CD44 receptor on resident macrophages to decrease zymosan/TLR2 mediated nuclear translocation of NF-κB. The negative feedback loop created by MSC through TSG-6 attenuates the inflammatory cascade that is initiated by resident macrophages and then amplified by mesothelial cells and probably other cells of the peritoneum. Because inflammation underlies many pathological processes, including immune responses, the results may explain the beneficial effects of MSCs and TSG-6 in several disease models. |
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Authors:
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Hosoon Choi; Ryang Hwa Lee; Nikolay Bazhanov; Joo Youn Oh; Darwin J Prockop |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-6 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Texas A&M Health Science Center, College of Medicine, Institute for Regenerative Medicine at Scott & White, Temple, TX, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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