Document Detail


Anti-inflammatory and proresolving lipid mediators.
MedLine Citation:
PMID:  18233953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The popular view that all lipid mediators are pro-inflammatory arises largely from the finding that nonsteroidal anti-inflammatory drugs block the biosynthesis of prostaglandins. The resolution of inflammation was widely held as a passive event until recently, with the characterization of novel biochemical pathways and lipid-derived mediators that are actively turned on in resolution and that possess potent anti-inflammatory and proresolving actions. A lipid-mediator informatics approach was employed to systematically identify new families of endogenous local-acting mediators from omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid) in resolving exudates, which also contain lipoxins and aspirin-triggered lipoxins generated from arachidonic acid. Given their potent bioactions, these new chemical mediator families were termed resolvins and protectins. Here, we review the recent advances in our understanding of the biosynthesis and stereospecific actions of these new proresolving mediators, which have also proven to be organ protective and antifibrotic.
Authors:
Charles N Serhan; Stephanie Yacoubian; Rong Yang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annual review of pathology     Volume:  3     ISSN:  1553-4006     ISO Abbreviation:  Annu Rev Pathol     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-05-13     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  101275111     Medline TA:  Annu Rev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-312     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Docosahexaenoic Acids / metabolism
Eicosapentaenoic Acid / physiology
Humans
Inflammation / physiopathology*
Inflammation Mediators / physiology*
Lipid Metabolism
Lipoxins / metabolism
Mice
Neutrophils / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
DK074448/DK/NIDDK NIH HHS; GM38765/GM/NIGMS NIH HHS; P50 DE016191/DE/NIDCR NIH HHS; P50 DE016191-03/DE/NIDCR NIH HHS; P50-DE016191/DE/NIDCR NIH HHS; R01 DK074448/DK/NIDDK NIH HHS; R01 DK074448-02/DK/NIDDK NIH HHS; R37 GM038765/GM/NIGMS NIH HHS; R37 GM038765-20/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; 0/Lipoxins; 25167-62-8/Docosahexaenoic Acids; AAN7QOV9EA/Eicosapentaenoic Acid
Comments/Corrections

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