| Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome. | |
| | |
MedLine Citation:
|
PMID: 22226987 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Obesity and metabolic syndrome are increasing global health problems. In addition to the malnutrition of a sedentary lifestyle, high calorie intake leads to obesity with many negative health consequences. Macrophages infiltrate adipose tissue and induce chronic inflammation by secreting pro-inflammatory cytokines, including COX-2 and iNOS, among other mediators of inflammation. Free fatty acids mediate adipose tissue signalling through toll-like receptor 4 and the expression of these pro-inflammatory mediators via NF-κB or JNK. PPAR γ activators can inhibit the activation of NF-κB, down-regulating the expression of pro-inflammatory cytokines. Here we provide an overview of how different culinary herbs and spices exert anti-inflammatory activities and the extent to which they activate PPAR α and PPAR γ, inhibit the activation of NF-κB, and enhance expression of anti-inflammatory cytokines. Spices can play essential roles as anti-inflammatory agents in our diet, acting as pan PPAR activators and improving insulin sensitivity, counteracting dyslipidaemia and weight gain. The effects of chronic inflammation caused by obesity are counteracted and, consequently, the progression of diseases associated with chronic inflammation slowed. |
| | |
Authors:
|
Alois Jungbauer; Svjetlana Medjakovic |
Related Documents
:
|
16264337 - Role of bacillus calmette-guérin as an immunomodulator for the prevention and treatmen... 8975927 - Infection by mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. 7982497 - Mycotin: a lectin involved in the adherence of mycobacteria to macrophages. 9670047 - Host resistance to intracellular infection: mutation of natural resistance-associated m... 155547 - Evidence against the presence of circulating immune complexes in chronic inflammatory b... 18783517 - Helicobacter pylori immunology and vaccines. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-5 |
Journal Detail:
|
Title: Maturitas Volume: - ISSN: 1873-4111 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7807333 Medline TA: Maturitas Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Biotechnology and Christian Doppler Laboratory of Receptor Biotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 18, 1190 Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification and functional analysis of the small membrane-associated protein pUL11 of avian infec...
Next Document: Age, weight and obesity.