Document Detail


Anti-inflammatory procyanidins and triterpenes in 109 apple varieties.
MedLine Citation:
PMID:  23013475     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We evaluated the potential of apple to reduce inflammation. Phenolic compounds and triterpenes were analysed in 109 apple cultivars. Total phenolics ranged from 29 to 7882 µg g-1 of fresh weight (FW) in the flesh and from 733 to 4868 µg g-1 FW in the skin, with fla-vanols including epicatechin and procyanidins as major components. Ursolic (44.7 to 3522 µg g-1 FW) and oleanolic (47.2 to 838 µg g-1 FW) acids dominated the skin triterpene profile. Five chemically contrasting cultivars were fractionated and their immune-modulating activity measured using two cell-based assays targeting key points in the inflammation process. Culti-vars exhibiting high contents of procyanidins were the most potent at inhibiting NF-κB while triterpene-rich fractions reduced the promoter activity of the gene of TNFα. This study pro-vides new insights into how apple genetic diversity could be used to alleviate inflammation.
Authors:
Christelle Martine André; Jeffrey M Greenwood; Edward G Walker; Maysoon Rassam; Michael Sullivan; Daniele Evers; Nigel Perry; William Laing
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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