| Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs. | |
| | |
MedLine Citation:
|
PMID: 22209879 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The present study was designed to evaluate the anti-inflammatory and antiarthritic activity of the new synthetic thienopyridine analogs. The anti-inflammatory activity of thienopyridines was assayed by using carrageenan; dextran and arachidonic acid induced paw edema models (acute), cotton pellet granuloma model (Sub acute) and Freund's complete adjuvant induced arthritis (chronic) in experimental rats. The compounds BN-4, BN-14 and BN-16 have shown significant inhibition of edema in carrageenan and arachidonic acid induced paw edema model at a dose of 100mg/kg compared to the dextran induced paw edema model and also showed significant inhibition in granuloma tissue formation and Freund's complete adjuvant induced arthritis in experimental rats. These thienopyridine analogs also inhibited the proinflammatory mediators such as Tumor necrosis factor (TNF)-α, Interleukin (IL)-1β and Nitric Oxide (NO) in Lipopolysaccharide (LPS) challenged murine macrophages. Ulcerogenecity study results revealed less ulcerogenic potential of BN-4, BN-14 and BN-16 compared to nonsteroidal anti-inflammatory drug (NSAID) indomethacin in rats. In conclusion, the new thienopyridine analogs were promising for the potential use as anti-inflammatory agents for both acute and chronic inflammatory disorders with low toxic effects. |
| | |
Authors:
|
Kuncha Madhusudana; Boyapati Shireesha; V G M Naidu; Sistla Ramakrishna; Banda Narsaiah; Akkinepally Raghuram Rao; Prakash V Diwan |
Related Documents
:
|
22246399 - Millimeter wave treatment induces apoptosis via activation of the mitochondrial-depende... 19300259 - Immune responses to alpha1,3 galactosyltransferase knockout pigs. 22222199 - The effect of adenosine on pro-inflammatory cytokine production by porcine t cells. 22185489 - Nfκb and glucocorticoid receptor activity in steroid resistance. 21856139 - Pathobionts of the gastrointestinal microbiota and inflammatory disease. 21571589 - Phagocyte responses towards aspergillus fumigatus. 19833119 - Experimental cryosurgery investigations in vivo. 18497309 - Lentiviral transduction of apoai into hematopoietic progenitor cells and macrophages: a... 16860949 - Naringenin-induced apoptosis via activation of nf-kappab and necrosis involving the los... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-24 |
Journal Detail:
|
Title: European journal of pharmacology Volume: - ISSN: 1879-0712 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Pharmacology Division, Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad, Andhra Pradesh-500607, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophili...
Next Document: The effect of sub-anesthetic and anesthetic ketamine on water maze memory acquisition, consolidation...