| Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference. | |
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MedLine Citation:
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PMID: 22030243 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lipoteichoic acid (LTA) mutants of lactobacilli suppress inflammation in animal models of experimental colitis. The fact that a single mutation of an administered Lactobacillus strain can result in enhanced probiotic efficacy is surprising given the genetic diversity and complexity of the intestinal niche, but at the same time exciting from a microbiological, immunological and gastroenterological point of view. In this Opinion article, we discuss the possible impacts of LTA modification in probiotic bacteria in the context of the current knowledge regarding the proinflammatory capacity of LTA, structure-activity relationships of LTA, intestinal LTA recognition in healthy and colitis conditions and anti-inflammatory molecules of lactobacilli. |
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Authors:
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Sarah Lebeer; Ingmar J J Claes; Jos Vanderleyden |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-24 |
Journal Detail:
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Title: Trends in microbiology Volume: - ISSN: 1878-4380 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Centre of Microbial and Plant Genetics, K.U. Leuven, Kasteelpark Arenberg 20, Box 2460, B-3001 Leuven, Belgium; Department of Bioscience Engineering, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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