Document Detail


Anti-inflammatory and mutagenic evaluation of medicinal plants used by Venda people against venereal and related diseases.
MedLine Citation:
PMID:  23276783     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGY RELEVANCE: Inflammation is a major risk factor for various human diseases including venereal diseases, often resulting in treatment complications. Plants have been traditionally used for treatment of many different diseases and have been successfully proven to be an alternative source in treatment of infectious diseases.
AIM OF THE STUDY: This study was aimed at evaluating the anti-inflammatory activities and the mutagenic properties of 12 medicinal plants used by the Venda people against venereal and related diseases.
MATERIALS AND METHODS: The plants were evaluated for their anti-inflammatory activity against the cyclooxygenase (COX-1 and -2) enzymes and genotoxicity using the Ames test, with and without S9 (metabolic activation) against Salmonella typhimurium tester strain TA98.
RESULTS: DCM and PE extracts of Adansonia digitata bark, Bolusanthus speciosus bark, Pterocarpus angolensis bark and Pappea capensis leaves and EtOH and water extracts of Bolusanthus speciosus stem and Ekebergia capensis bark showed the best anti-inflammatory activity in both COX-1 and -2 assays at 250 μg/ml. These were further evaluated at three other concentrations (31.25, 62.5, and 125 μg/ml) to determine IC50 values. Water extracts of Ekebergia capensis bark showed the best IC50 value towards COX-1. The Ames test revealed that all plant extracts were non-mutagenic towards Salmonella typhimurium strain TA98 except for Elephantorrhiza burkei and Ekebergia capensis that showed weak mutagenicity.
CONCLUSION: The active plants may offer a new source of chemicals for the effective treatment of anti-inflammatory conditions related to venereal diseases.
Authors:
R B Mulaudzi; A R Ndhlala; M G Kulkarni; J F Finnie; J Van Staden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-28
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  146     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-08-13     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / pharmacology*
Cyclooxygenase 1 / metabolism
Cyclooxygenase 2 / metabolism
Cyclooxygenase Inhibitors / pharmacology*
Humans
Medicine, African Traditional
Mutagenicity Tests
Phytotherapy
Plant Extracts / pharmacology*
Plants, Medicinal*
Salmonella typhi / drug effects,  genetics
Sexually Transmitted Diseases / drug therapy
South Africa
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cyclooxygenase Inhibitors; 0/Plant Extracts; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2

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