| Anti-inflammatory and mutagenic evaluation of medicinal plants used by Venda people against venereal and related diseases. | |
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MedLine Citation:
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PMID: 23276783 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ETHNOPHARMACOLOGY RELEVANCE: Inflammation is a major risk factor for various human diseases including venereal diseases, often resulting in treatment complications. Plants have been traditionally used for treatment of many different diseases and have been successfully proven to be an alternative source in treatment of infectious diseases AIM OF THE STUDY: This study was aimed at evaluating the anti-inflammatory activities and the mutagenic properties of 12 medicinal plants used by the Venda people against venereal and related diseases. MATERIALS AND METHODS: The plants were evaluated for their anti-inflammatory activity against the cyclooxygenase (COX-1 and -2) enzymes and genotoxicity using the Ames test, with and without S9 (metabolic activation) against Salmonella typhimurium tester strain TA98. RESULTS: DCM and PE extracts of A. digitata bark, B. speciosus bark, P. angolensis bark and P. capensis leaves and EtOH and water extracts of B. speciosus stem and E. capensis bark showed the best anti-inflammatory activity in both COX-1 and-2 assays at 250μg/ml. These were further evaluated at three other concentrations (31.25, 62.5, and 125μg/ml) to determine IC(50) values. Water extracts of E. capensis bark showed the best IC(50) value towards COX-1. The Ames test revealed that all plant extracts were non-mutagenic toward S. typhimurium strain TA98 except for E. burkei and E. capensis that showed weak mutagenicity. CONCLUSION: The active plants may offer a new source of chemicals for the effective treatment of anti-inflammatory conditions related to venereal diseases. |
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Authors:
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R B Mulaudzi; A R Ndhlala; M G Kulkarni; J F Finnie; J Van Staden |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-28 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: - ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2013-1-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
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Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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