| Anti-inflammatory medication after muscle injury. A treatment resulting in short-term improvement but subsequent loss of muscle function. | |
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MedLine Citation:
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PMID: 7593059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of flurbiprofen, a non-steroidal anti-inflammatory drug, on muscles that had been subjected to exercise-induced injury. The muscles of the anterior compartment in the limbs of rabbits were cyclically activated as the ankle was simultaneously moved through passive plantar flexion every two seconds for thirty minutes. This treatment imposed acute passive lengthening (eccentric contractions) of the maximally contracted muscles of the anterior compartment. After the eccentric contraction-induced muscle injury, one group of rabbits was treated with oral administration of flurbiprofen, two times a day for six days, while the other group of rabbits served as untreated controls. The contractile, histological, and ultrastructural properties of the muscles were measured before the initial exercise and at three, seven, and twenty-eight days afterward. The group that was treated with flurbiprofen demonstrated a more complete functional recovery than the untreated controls at three and seven days but had a deficit in torque and force generation at twenty-eight days. The administration of flurbiprofen also resulted in a dramatic preservation of the intermediate filament protein desmin. After three days, the proportion of fibers of the extensor digitorum longus that lost desmin-staining was significantly greater in the untreated controls than in the treated animals (34 +/- 4.1 compared with 2.9 +/- 1.7 per cent) (p < 0.001), a finding that supports the concept of a short-term protective effect. However, the muscles in the treated animals still mounted a dramatic regenerative response, as indicated by the expression of embryonic myosin. Early in the recovery period (at three days), significantly fewer fibers of the extensor digitorum longus (2.2 +/- 1.4 per cent) expressed embryonic myosin in the treated animals than in the untreated controls (11.8 +/- 1.9 per cent) (p < 0.001). However, at seven days, the expression of embryonic myosin by the muscles from the treated animals (19.5 +/- 11.9 per cent) actually exceeded that of the muscles from the untreated controls (16.2 +/- 4.1 per cent). This finding suggests either a delayed or an ineffectual regenerative response by the muscles in the treated animals. |
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Authors:
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D K Mishra; J Fridén; M C Schmitz; R L Lieber |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of bone and joint surgery. American volume Volume: 77 ISSN: 0021-9355 ISO Abbreviation: J Bone Joint Surg Am Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-11-27 Completed Date: 1995-11-27 Revised Date: 2010-10-25 |
Medline Journal Info:
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Nlm Unique ID: 0014030 Medline TA: J Bone Joint Surg Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1510-9 Citation Subset: AIM; IM; S |
Affiliation:
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Department of Orthopaedics, Veterans Administration Medical Center, San Diego, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology,
therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology, therapeutic use* Desmin / drug effects, metabolism Flurbiprofen / pharmacology, therapeutic use* Isometric Contraction Male Muscle Contraction Muscle Fibers, Skeletal / drug effects, metabolism, ultrastructure Muscle, Skeletal / drug effects*, physiopathology, ultrastructure Myofibrils / drug effects, ultrastructure Myosins / drug effects, metabolism Physical Exertion / physiology* Rabbits Regeneration / drug effects Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AR 40050/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Desmin; 5104-49-4/Flurbiprofen; EC 3.6.4.1/Myosins |
| Comments/Corrections | |
Comment In:
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J Bone Joint Surg Am. 1997 Aug;79(8):1270-1
[PMID:
9278088
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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