Document Detail

Anti-inflammatory mediators as physiological and pharmacological regulators of parturition.
MedLine Citation:
PMID:  21895479     Owner:  NLM     Status:  MEDLINE    
Increasing evidence highlights parturition as an inflammatory event characterized by leukocyte influx and proinflammatory mediator production in the intrauterine environment. While the mechanisms responsible for the initiation of this inflammatory cascade are not well understood, it is clear that these inflammatory events must be tightly regulated as the premature activation of these inflammatory signals is associated with adverse pregnancy outcomes, such as preterm labor, which is the leading cause of neonatal mortality and morbidity. In this article we highlight the importance of anti-inflammatory factors in regulating the inflammatory events surrounding parturition and discuss the use of anti-inflammatory mediators as potential novel therapeutic agents in the treatment of inflammation-induced preterm labor.
Sara F Rinaldi; James L Hutchinson; Adriano G Rossi; Jane E Norman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  7     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-07     Completed Date:  2011-12-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  675-96     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents / immunology*,  therapeutic use*
Inflammation / drug therapy,  immunology
Parturition / drug effects*,  immunology*
Premature Birth / drug therapy*,  immunology*
Grant Support
G0601481//Medical Research Council; G1002033//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Anti-Inflammatory Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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