| Anti-inflammatory functions of the "apoptotic" caspases. | |
| | |
MedLine Citation:
|
PMID: 20958311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The two main known functions of the caspases act antagonistically in regulating inflammation. "Inflammatory" caspases trigger inflammation by catalyzing the processing of IL-1β precursors and other proinflammatory cytokines. In contrast, "apoptotic" caspases safeguard against the triggering of inflammation by imposing a cell-death form that withholds release of alarmins by dying cells and dictates generation of anti-inflammatory mediators. These antagonizing functions are exerted by evolution-related mechanisms. Studies of the function of caspase-8, an enzyme-mediating apoptotic cell-death induction in response to TNF-family ligands, reveal that it blocks inflammation in additional ways. One way is by restricting activation of the RIG-I complex by foreign ribonucleic acid. Chronic skin inflammation in mice with caspase-8-deficient epidermis is associated with constitutive activation of the RIG-I complex in keratinocytes. This activation is apparently prompted by nucleic acids released from epidermal cells that disintegrate during cornification, and becomes chronic because it is not restricted by caspase-8. |
| | |
Authors:
|
David Wallach; Tae-Bong Kang; Akhil Rajput; Jin-Chul Kim; Konstantin Bogdanov; Seung-Hoon Yang; Andrew Kovalenko |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of the New York Academy of Sciences Volume: 1209 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-20 Completed Date: 2010-11-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 17-22 Citation Subset: IM |
Copyright Information:
|
© 2010 New York Academy of Sciences. |
Affiliation:
|
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel. d.wallach@weizmann.ac.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apoptosis* Caspases / metabolism* Humans Inflammation / enzymology* Signal Transduction |
| Chemical | |
Reg. No./Substance:
|
EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Apoptosis and autoimmune diseases.
Next Document: TAM receptors and the clearance of apoptotic cells.