| Anti-inflammatory and Anti-fibrotic Effects of Naringenin in Diabetic Mice. | |
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MedLine Citation:
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PMID: 22117528 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Renal protective effects of naringenin at 0.5, 1 and 2% of the diet in diabetic mice were examined. Naringenin supplement at 1 and 2% increased its deposit in liver and kidney of diabetic mice. Compared with diabetic control group, naringenin treatments at 1 and 2% lowered plasma levels of glucose and blood urea nitrogen, as well as increased insulin level and creatinine clearance (P<0.05). Naringenin treatments dose-dependently reduced renal tumor necrosis factor-alpha level and expression (P<0.05); but only at 1 and 2% significantly decreased production and expression of interleukin (IL)-1beta, IL-6 and monocyte chemoattractant protein-1 (P<0.05). Naringenin intake at 2% declined renal formation and expression of type IV collagen, fibronectin, and transforming growth factor-beta1 (P<0.05). This compound at 1 and 2% lowered protein kinase C activity, and suppressed nuclear factor kappa B (NF-κB) p65 activity, mRNA expression, and protein production in kidney. However, this agent only at 2% diminished NF-κB p50 activity, mRNA expression, and protein production (P<0.05). These results support that naringenin could attenuate diabetic nephropathy via its anti-inflammatory and anti-fibrotic activities. |
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Authors:
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Shih-Jei Tsai; Chin-Shiu Huang; Mei-Chin Mong; Wing-Yiu Kam; Hui-Ying Huang; Mei-Chin Yin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-28 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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