| Anti-inflammatory evaluation of Coronopus didymus in the pleurisy and paw oedema models in mice. | |
| | |
MedLine Citation:
|
PMID: 20026396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
ETHNOPHARMACOLOGICAL RELEVANCE: Mastrun?o (Coronopus didymus--CD) is currently considered as a medicinal specie often used in Brazil, especially in southeast region, for the treatment of several diseases in which pain and inflammation are common. Treatment with the plant can be done by infusion, decoction, or through food. The aim of this study was: to investigate the anti-inflammatory effect of hydroalcoholic extract obtained from the leaves of CD following the traditional procedure. MATERIALS AND METHODS: The anti-inflammatory activity was determined using mouse of pleurisy and paw oedema models, both process being induced by different flogistic agents such as: carrageenan (Cg), bradykinin (BK), histamine (HIS), substance P (SP), dextran (DEX) or prostaglandin E(2) (PGE(2)). We evaluated the effect of CD (200-600 mg/kg) administered by oral route (p.o.) upon leukocytes migration, myeloperoxidase (MPO), and adenosine-deaminase (ADA) activities and nitric oxide (NO) levels. RESULTS: CD (200-600 mg/kg) inhibited the leukocytes by 60.0+/-1.42%, neutrophils by 82.75+/-1.29%, MPO by 42.30+/-4.23%, and ADA activities by 57.89+/-1.94%, as well as NO levels by 64.28+/-2.15% in Cg induced pleurisy. CD also inhibited total and differential leukocytes in the pleurisy induced by BK (1.30+/-0.11/0.29+/-0.02), HIS (1.20+/-0.09/0.42+/-0.05) and SP (0.74+/-0.06/0.14+/-0.01). In addition, CD was effective in reducing paw oedema induced by Cg by 72.79+/-1.13%, SP by 68.26.+/-0.78%, BK by 66.66.+/-0.77%, PGE(2) by 53.346.+/-1.18 and DEX by 65.14+/-2.35%. CONCLUSION: Several mechanisms, including the inhibition of enzymes (MPO and ADA) and mediators (BK, HIS, SP, NO and PGE(2)) release and/or action, appear to account for the anti-inflammatory effect of Coronopus didymus. |
| | |
Authors:
|
Tereza Cristina Pamplona Mosimann Busnardo; Cristina Padoani; Ticiana Camila Mora; Maique Weber Biavatti; T?nia Silvia Fr?de; Cristiani B?rger; Vanessa D Claudino; Eduardo Monguilhote Dalmarco; M?rcia Maria de Souza |
Related Documents
:
|
12065506 - Regulation of proinflammatory cytokines in human lung epithelial cells infected with my... 21477856 - Immunological tolerance in a mouse model of immune-mediated liver injury induced by 16,... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-22 |
Journal Detail:
|
Title: Journal of ethnopharmacology Volume: 128 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-03-09 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 519-25 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Centro de Ci?ncias da Sa?de, CCS, Mestrado em Ci?ncias Farmac?uticas Universidade do Vale do Itaja?, UNIVALI. Itaja?, SC, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Deaminase
/
pharmacology Animals Anti-Inflammatory Agents / administration & dosage Bradykinin / pharmacology Brazil Carrageenan / pharmacology Edema / chemically induced, drug therapy* Histamine / pharmacology Inflammation / chemically induced, drug therapy* Leukocyte Count Leukocytes / drug effects Mice Neutrophils / drug effects Nitric Oxide / pharmacology Peroxidase / pharmacology Plant Leaves / chemistry Pleurisy / chemically induced, drug therapy* Rats Substance P / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 10102-43-9/Nitric Oxide; 33507-63-0/Substance P; 51-45-6/Histamine; 58-82-2/Bradykinin; 9000-07-1/Carrageenan; EC 1.11.1.7/Peroxidase; EC 3.5.4.4/Adenosine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2...
Next Document: Protective effect of Calendula officinalis extract against UVB-induced oxidative stress in skin: Eva...