Document Detail

Anti-inflammatory effects of rebamipide according to Helicobacter pylori status in patients with chronic erosive gastritis: a randomized sucralfate-controlled multicenter trial in China-STARS study.
MedLine Citation:
PMID:  18288617     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to investigate the effects of rebamipide on symptom, histology, endogenous prostaglandin, and mucosal oxygen free radicals in chronic erosive gastritis (CEG) patients by using sucralfate as a control. The trial also examined whether Helicobacter pylori infection would affect rebamipide-induced protection. A total of 453 endoscopy-confirmed CEG patients from 11 hospitals in China were enrolled in the study. They randomly received either rebamipide (100 mg t.i.d) or sucralfate (1.0 t.i.d) for 8 weeks with a ratio of 3:1. Per-protocol analysis (n = 415) showed the accumulated symptom score in the rebamipide group dropped from 5.54 +/- 0.97 to 0.80 +/- 0.47 after 8 weeks (P < 0.001 versus control). The endoscopic inflammation score in rebamipide group also decreased from 2.65 +/- 0.09 to 0.60 +/- 0.10, which showed better effects than sucralfate. It was shown a significant improvement (P < 0.01) in prostaglandin E2 (PGE(2)) contents in rebamipide-treated subjects mucosa (225.4 +/- 18.3 pg/g versus 266.7 +/- 14.7 pg/g) compared with that in sucralfate group after 8 weeks of treatment. Malondialdehyde (MDA) contents were significantly depressed both in the trial and control group. When Helicobacter pylori infection was considered, no statistically difference was found in the effect of rebamipide on either symptom or inflammation scores. In conclusion, Rebamipide demonstrated a stronger suppressive effect on the mucosal inflammation in chronic erosive gastritis than sucralfate. The gastroprotection induced by rebamipide is not influenced by H. pylori infection, which indicates its usage in the treatment of H. pylori-associated CEG.
Yiqi Du; Zhaoshen Li; Xianbao Zhan; Jie Chen; Jun Gao; Yanfang Gong; Jianlin Ren; Liping He; Zhijian Zhang; Xiaozhong Guo; Jianshen Wu; Zibin Tian; Ruihua Shi; Bo Jiang; Dianchun Fang; Youming Li
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2008-02-21
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2008-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2886-95     Citation Subset:  AIM; IM    
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
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MeSH Terms
Alanine / analogs & derivatives*,  therapeutic use
Anti-Inflammatory Agents / therapeutic use*
Anti-Ulcer Agents / therapeutic use*
Dinoprostone / metabolism
Gastric Mucosa / metabolism,  microbiology
Gastritis / drug therapy*,  ethnology,  microbiology*
Helicobacter Infections / complications*
Helicobacter pylori / pathogenicity
Malondialdehyde / metabolism
Middle Aged
Quinolones / therapeutic use*
Sucralfate / therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Ulcer Agents; 0/Quinolones; 111911-87-6/rebamipide; 363-24-6/Dinoprostone; 54182-58-0/Sucralfate; 542-78-9/Malondialdehyde; 56-41-7/Alanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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