| Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 12957433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to assess the effects of regular physical exercise on local inflammatory parameters in the skeletal muscle of patients with chronic heart failure (CHF). BACKGROUND: Inflammatory activation with increased serum cytokine levels and expression of inducible nitric oxide synthase (iNOS) in the myocardium and peripheral skeletal muscles has been described in CHF. METHODS: Twenty male patients with stable CHF (left ventricular ejection fraction 25 +/- 2%; age 54 +/- 2 years) were randomized to a training group (n = 10) or a control group (n = 10). At baseline and after six months, serum samples and vastus lateralis muscle biopsies were obtained. Serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1-beta levels were measured by enzyme-linked immunosorbent assay, local cytokine, and iNOS expression by real-time polymerase chain reaction. RESULTS: Exercise training improved peak oxygen uptake by 29% in the training group (from 20.3 +/- 1.0 to 26.1 +/- 1.5 ml/kg. min; p < 0.001 vs. control group). While serum levels of TNF-alpha, IL-6, and IL-1-beta remained unaffected by training, local skeletal muscle TNF-alpha decreased from 1.9 +/- 0.4 to 1.2 +/- 0.3 relative U (p < 0.05 for change vs. control group), IL-6 from 71.3 +/- 16.5 to 41.3 +/- 8.8 relative U (p < 0.05 vs. begin), and IL-1-beta from 2.7 +/- 1.1 to 1.4 +/- 0.6 relative U (p = 0.02 vs. control group). Exercise training also reduced local iNOS expression by 52% (from 6.3 +/- 1.2 to 3.0 +/- 1.0 relative U; p = 0.007 vs. control group). CONCLUSIONS: Exercise training significantly reduced the local expression of TNF-alpha, IL-1-beta, IL-6, and iNOS in the skeletal muscle of CHF patients. These local anti-inflammatory effects of exercise may attenuate the catabolic wasting process associated with the progression of CHF. |
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Authors:
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Stephan Gielen; Volker Adams; Sven Möbius-Winkler; Axel Linke; Sandra Erbs; Jiangtao Yu; Werner Kempf; Andreas Schubert; Gerhard Schuler; Rainer Hambrecht |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 42 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-05 Completed Date: 2003-10-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 861-8 Citation Subset: AIM; IM |
Affiliation:
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Universität Leipzig, Herzzentrum GmbH, Department of Internal Medicine & Cardiology, Strümpellstrasse 39, 04289 Leipzig, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Case-Control Studies Disease Progression Enzyme-Linked Immunosorbent Assay Exercise Therapy / methods*, standards Heart Failure / complications, diagnosis, immunology*, metabolism, rehabilitation* Humans Inflammation Interleukin-1 / analysis*, blood Interleukin-6 / analysis*, blood Male Middle Aged Muscle, Skeletal / chemistry*, immunology* Nitric Oxide Synthase / analysis*, blood Oxygen Consumption Prospective Studies Treatment Outcome Tumor Necrosis Factor-alpha / analysis*, metabolism Wasting Syndrome / etiology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2003 Sep 3;42(5):869-72
[PMID:
12957434
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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