| Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction. | |
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MedLine Citation:
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PMID: 21864631 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ginger extracts have been reported to have anti-inflammatory, anti-oxidant, and anti-cancer effects. [6]-shogaol is one of the most bioactive components of ginger rhizomes. This study assessed the [6]-shogaol's ability to protect cultured primary rat astrocytes against lipopolysaccharide (LPS)-induced inflammation. [6]-shogaol was shown to suppress the release of pro-inflammatory cytokines and decreased the level of inducible nitric oxide syntheses (iNOS), cyclooxygenase-2 (COX-2), and phospho-NF-kB in LPS-treated astrocytes. Furthermore, [6]-shogaol treatment markedly up-regulated histone H3 acetylation and suppressed histone deacetylase (HDAC)1 expression. In addition, [6]-shogaol treatment also increased the expression of heat-shock protein (HSP)70. The neuroprotective, neurotrphic, and anti-inflammatory properties of [6]-shogaol may be translated to improvements in neurological performance. [6]-Shogaol's ability to inhibit HDAC was comparable to that of commonly used HDAC inhibitors Trichostatin A and MS275. Taken together, our results suggest that [6]-shogaol can significantly attenuate a variety of neuroinflammatory responses by inducing HSP70, that is associated with HDAC inhibition in cortical astrocytes. |
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Authors:
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Sehwan Shim; Sokho Kim; Dea-Seung Choi; Young-Bae Kwon; Jungkee Kwon |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-16 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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