| Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. | |
| | |
MedLine Citation:
|
PMID: 22318967 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
These studies were undertaken to extend emerging evidence that β(2) adrenergic receptor (β(2)AR) agonists, in addition to their bronchorelaxing effects, may have broad anti-inflammatory effects in the lung following onset of experimental acute lung injury (ALI). Young male C57BL/6 mice (25 g) developed ALI following airway deposition of bacterial LPS or IgG immune complexes in the absence or presence of appropriate stereoisomers (enantiomers) of β(2)AR agonists, albuterol or formoterol. Endpoints included albumin leak into lung and buildup of polymorphonuclear neutrophils and cytokines/chemokines in bronchoalveolar fluids. Both β(2)AR agonists suppressed lung inflammatory parameters (IC(50)=10(-7) M). Similar effects of β(2)AR agonists on mediator release were found when mouse macrophages were stimulated in vitro with LPS. The protective effects were associated with reduced activation (phosphorylation) of JNK but not of other signaling proteins. Collectively, these data suggest that β(2)AR agonists have broad anti-inflammatory effects in the setting of ALI. While β(2)AR agonists suppress JNK activation, the extent to which this can explain the blunted lung inflammatory responses in the ALI models remains to be determined.-Bosmann, M., Grailer, J. J., Zhu, K., Matthay, M A., Vidya Sarma, J., Zetoune, F. S., Ward, P. A. Anti-inflammatory effects of β(2) adrenergic receptor agonists in experimental acute lung injury. |
| | |
Authors:
|
Markus Bosmann; Jamison J Grailer; Ketong Zhu; Michael A Matthay; J Vidya Sarma; Firas S Zetoune; Peter A Ward |
Related Documents
:
|
22287607 - Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced br... 22592747 - Mechanisms of methicillin-resistant staphylococcus aureus pneumonia-induced intestinal ... 22407577 - Peeking into the secret life of neutrophils. 8701587 - Immunization with a soluble recombinant hiv protein entrapped in biodegradable micropar... 22287607 - Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced br... 19361867 - Ovine trophoblast is a primary source of tnfalpha during chlamydophila abortus infection. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
|
Title: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: - ISSN: 1530-6860 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804484 Medline TA: FASEB J Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
*Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA; and. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fried-Potato Diet Causes Vitamin A Deficiency in an Autistic Child.
Next Document: New experimental data linking secondhand smoke exposure to lung cancer in nonsmokers.