Document Detail

Anti-inflammatory effects of 17beta-estradiol pretreatment in men after coronary artery surgery.
MedLine Citation:
PMID:  11505349     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the anti-inflammatory and hemodynamic effects of 17beta-estradiol in men undergoing elective coronary artery bypass graft surgery (CABG). DESIGN: Prospective, randomized, controlled. SETTING: Operating room and intensive care unit in a university hospital. PARTICIPANTS: Twenty-one men undergoing primary, elective CABG surgery. INTERVENTION: 17beta-estradiol, 2mg, was given orally twice in 14 hours before the operation. MEASUREMENTS AND MAIN RESULTS: Leukocyte counts, plasma myeloperoxidase, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-10 were measured perioperatively. Leukocyte counts were lower in the 17beta-estradiol group than in controls at 6 hours (11.4 +/- 2.0 hours v 15.5 +/- 4.7 hours x 10(9)/L) and 20 hours (11.6 +/- 1.9 hours v 13.6 +/- 2.5 hours x 10(9)/L) after reperfusion (p = 0.03). The release of myeloperoxidase was lower in the 17beta-estradiol group than in controls (5 minutes; 634.4 +/- 213.1 microg/mL v 773.1 +/- 209.3 microg/mL; 4 hours, 305.0 +/- 108.0 microg/mL v 441.3 +/- 191.6 microg/mL; p = 0.02). Systemic vascular resistance index was lower just after cardiopulmonary bypass, and cardiac index was higher postoperatively in the 17beta-estradiol group as compared with controls. CONCLUSION: Pretreatment with 17beta-estradiol can limit leukocyte activation in men after CABG surgery.
M Wei; P Kuukasjärvi; S Kaukinen; J Laurikka; E Pehkonen; S Laine; E Moilanen; R Metsänoja; M Tarkka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  15     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-15     Completed Date:  2001-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-9     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company.
Division of Cardiovascular Surgery, Department of Anesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland.
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MeSH Terms
Administration, Oral
Anti-Inflammatory Agents / administration & dosage*
Coronary Artery Bypass*
Cytokines / blood*
Estradiol / administration & dosage*,  pharmacology
Hemodynamics / drug effects
Interleukin-10 / blood
Interleukin-6 / blood
Interleukin-8 / blood
Leukocyte Count
Lymphocyte Activation
Middle Aged
Peroxidase / blood
Prospective Studies
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 50-28-2/Estradiol; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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