Document Detail


Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss.
MedLine Citation:
PMID:  19695853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: We investigated the effect of different exercise modalities on high sensitivity-C reactive protein (hs-CRP) and other inflammatory markers in patients with type 2 diabetes and the metabolic syndrome.
METHODS AND RESULTS: Eighty-two patients were randomized into 4 groups: sedentary control (A); receiving counseling to perform low-intensity physical activity (B); performing prescribed and supervised high-intensity aerobic (C) or aerobic+resistance (D) exercise (with the same caloric expenditure) for 12 months. Evaluation of leisure-time physical activity and assessment of physical fitness, cardiovascular risk factors and inflammatory biomarkers was performed at baseline and every 3 months. Volume of physical activity increased and HbA(1c) decreased in Groups B-D. VO(2max), HOMA-IR index, HDL-cholesterol, waist circumference and albuminuria improved in Groups C and D, whereas strength and flexibility improved only in Group D. Levels of hs-CRP decreased in all three exercising groups, but the reduction was significant only in Groups C and D, and particularly in Group D. Changes in VO(2max) and the exercise modalities were strong predictors of hs-CRP reduction, independent of body weight. Leptin, resistin and interleukin-6 decreased, whereas adiponectin increased in Groups C and D. Interleukin-1β, tumor necrosis factor-α and interferon-γ decreased, whereas anti-inflammatory interleukin-4 and 10 increased only in Group D.
CONCLUSION: Physical exercise in type 2 diabetic patients with the metabolic syndrome is associated with a significant reduction of hs-CRP and other inflammatory and insulin resistance biomarkers, independent of weight loss. Long-term high-intensity (preferably mixed) training, in addition to daytime physical activity, is required to obtain a significant anti-inflammatory effect.
Authors:
S Balducci; S Zanuso; A Nicolucci; F Fernando; S Cavallo; P Cardelli; S Fallucca; E Alessi; C Letizia; A Jimenez; F Fallucca; G Pugliese
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  20     ISSN:  1590-3729     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  608-17     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier B.V. All rights reserved.
Affiliation:
Metabolic Fitness Association, Monterotondo, Rome, Italy. s.balducci@hctdiabete.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
C-Reactive Protein / analysis*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Diabetes Mellitus, Type 2 / immunology*
Exercise*
Female
Humans
Inflammation / prevention & control*
Interleukin-6 / blood
Male
Metabolic Syndrome X / immunology*
Middle Aged
Tumor Necrosis Factor-alpha / blood
Weight Loss*
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

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