| Anti-inflammatory effect of enzymatic hydrolysate of corn gluten in an experimental model of colitis. | |
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MedLine Citation:
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PMID: 20487224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Intestinal bacteria are thought to be involved in the initiation and perpetuation of inflammatory bowel diseases. Prebiotics (non-digestable dietary carbohydrate) have beneficial properties that alter the intestinal flora and contain glutamine-rich protein. Glutamine significantly decreases indices of inflammation. In this study, an enzymatic hydrolysate of corn gluten (EHCG) was administered by gavage to Sprague-Dawley rats fed an elemental diet to determine whether EHCG can ameliorate experi- mental colitis. METHODS: Colitis was induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid after 10 days' daily oral administration of EHCG at 100 and 300 mg/kg. Macroscopic damage was assessed using a scoring system. The mucosa homogenate was sonicated and myeloperoxidase activity and histamine levels measured. KEY FINDINGS: Treatment with EHCG significantly decreased the severity of injury and reduced myeloperoxidase activity and histamine levels in the distal colon mucosa. CONCLUSIONS: EHCG may have therapeutic benefit as a supplement in enteral nutrition for patients with inflammatory bowel diseases. |
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Authors:
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Miyako Mochizuki; Hayato Shigemura; Noboru Hasegawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-10 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 389-92 Citation Subset: IM |
Affiliation:
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Department of Human Life Science, Graduate School of Human Life Science, Gifu Women's University, Gifu, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, therapeutic use* Colitis / chemically induced, pathology, prevention & control* Colon, Descending / drug effects, metabolism, pathology Dietary Supplements Disease Models, Animal Dose-Response Relationship, Drug Food, Formulated / adverse effects Glutens / metabolism* Histamine / metabolism Intestinal Mucosa / drug effects, metabolism, pathology Male Peroxidase / metabolism Protein Hydrolysates / administration & dosage, therapeutic use* Rats Rats, Sprague-Dawley Seeds / chemistry* Severity of Illness Index Trinitrobenzenesulfonic Acid / toxicity Zea mays / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Protein Hydrolysates; 2508-19-2/Trinitrobenzenesulfonic Acid; 51-45-6/Histamine; 8002-80-0/Glutens; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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