Document Detail


Anti-inflammatory drugs and the kidney.
MedLine Citation:
PMID:  18203065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors (coxibs) enjoy widespread use in clinical practice, leading to a remarkable frequency of unwanted renal side effects. In most cases, NSAID-induced acute renal failure or acute kidney injury is hemodynamically mediated. Clinical syndromes associated with NSAID use include acute renal failure, acute interstitial nephritis, worsening of chronic kidney disease (CKD), salt and water retention and hypertension. Careful monitoring of renal function is advisable in patients at increased risk such as elderly individuals with compromised cardiac reserve, and diabetics.
Authors:
A A House; S Silva Oliveira; C Ronco
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  30     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1042-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Nephrology, University of Western Ontario, London, Canada. andrew.house@lhsc.on.ca
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  pharmacology
Humans
Kidney / drug effects
Kidney Diseases / chemically induced*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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