Document Detail

Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury.
MedLine Citation:
PMID:  10190769     Owner:  NLM     Status:  MEDLINE    
The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2* production, and markers of muscle injury. Males (n=10) performed 2 bouts of one-arm eccentric exercise on opposite arms separated by three weeks. Subjects received 2400 mg x d(-1) of ibuprofen or a placebo 5 d before exercise and during 10 d of recovery. Measurements were made before the treatments, pre-exercise, at 4 h, and at 1, 2, 3, 4 and 10 d post-exercise. Circulating neutrophil counts were similar between the treatments at the sampling points. Neutrophil counts were higher (p<0.05) for ibuprofen and were elevated (p<0.05) at 4h post-exercise relative to pre-exercise in both treatments. Stimulated neutrophil O2* production was lower for ibuprofen relative to placebo at pre-exercise and was increased (p<0.05) at 4 h and 4 d of both treatments. CK activity at 3 d post-exercise was lower (p<0.05) for ibuprofen relative to placebo. Isometric strength, soreness, tenderness, and arm angles were similar between the treatments. In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise.
F X Pizza; D Cavender; A Stockard; H Baylies; A Beighle
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sports medicine     Volume:  20     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-05     Completed Date:  1999-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM    
Texas Christian University, Exercise Physiology Laboratory, Fort Worth, Texas, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Ibuprofen / administration & dosage*
Muscle, Skeletal / drug effects,  pathology*
Neutrophils / drug effects*,  metabolism,  physiology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 15687-27-1/Ibuprofen

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