| Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides. | |
MedLine Citation:
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PMID: 16223515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pedilanthus tithymaloides (L.) Poit. (Euphorbiaceae) is a low tropical American shrub with a reported wide range of healing properties such as emetic, anti-inflammatory, antibiotic, antiseptic, antihemorrhagic, antiviral, antitumoral, and abortive. In the present study, a tincture from P. tithymaloides collected in Cuba was evaluated for its in vivo anti-inflammatory activity, using the rat paw oedema assay, and for its in vitro scavenging effects on reactive oxygen species (ROS) (HO*, O2*-, HOCl, ROO* and H2O2), reactive nitrogen species (RNS) (ONOO- and *NO), and DPPH* radical. The protein, free amino acid, and phenolic contents of the tincture were also determined. Pertaining to the anti-inflammatory activity, the intraperitoneal administration of the tincture inhibited carrageenan-induced rat paw oedema, whereas in the scavenging assays the tincture showed to be effective against all the assayed ROS and RNS, specially for HO* (IC50 = 345+/-77 microg/mL), O2*- (IC50 = 143+/-7 microg/mL), HOCl (IC50 = 113+/-20 microg/mL), ONOO- (IC50 = 44+/-3 microg/mL), and *NO (IC50 = 54+/-4 microg/mL), but displayed weak activity in the DPPH* assay. The protein content of the tincture was 0.70%, and twenty free amino acids were identified and quantified. The content of total phenolics was 17.4+/-0.15 mg of gallic acid equivalents (GAE)/g dry material. These results provide scientific support for the empirical use of P. tithymaloides tincture as an anti-inflammatory medicine. |
Authors:
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Pedro Abreu; Susan Matthew; Tania González; David Costa; Marcela A Segundo; Eduarda Fernandes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-11 |
Journal Detail:
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Title: Life sciences Volume: 78 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-04-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 1578-85 Citation Subset: IM |
Affiliation:
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REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, Portugal. pma@dq.fct.unl.pt |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / therapeutic use* Antioxidants / therapeutic use* Biological Assay Edema / chemically induced, drug therapy* Euphorbiaceae / chemistry* Inhibitory Concentration 50 Male Plant Extracts / therapeutic use Rats Rats, Sprague-Dawley Reactive Oxygen Species / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antioxidants; 0/Plant Extracts; 0/Reactive Oxygen Species |
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