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Anti-inflammatory and anticoagulant properties of the protein C system in inflammatory bowel disease.
MedLine Citation:
PMID:  22538795     Owner:  NLM     Status:  Publisher    
INTRODUCTION: In patients with inflammatory bowel disease (IBD) there has been demonstrated disbalance between procoagulant, anticoagulant and fibrynolytic factors. The hemostasis system is an indispensable element of each inflammatory process. Deficiencies in the protein C (PC) pathway not only promote thrombosis, but also amplify the inflammatory process. PATIENTS AND METHODS: The PC system components (soluble thrombomodulin (sTM), PC, free protein S (PS)) were measured in 55 consecutive patients with ulcerative colitis (UC), 50 with Crohn's disease (CD) and in 41 healthy volunteers. Associations of the PC system components with disease activity, hemostatic variables and inflammatory markers were assessed. RESULTS: sTM value in UC was higher as compared to the controls (p=0.0042). In IBD PC activity was higher and PS level was lower as compared to the controls (p<0.001). TNF-alfa level was higher in IBD patients and Il-6 level was higher in CD patients.  There was a positive correlation between sTM level and PC as well PS level in UC group (r=0.28 and r= 0.34, respectively, p<0.05). Only PC level correlated with UC activity (r=0.3, p<0.05).  No correlations between TNF-alfa, Il-6, CRP and  PC, PS, sTM levels were found. CONCLUSIONS: PC pathway is defective in both CD and UC patients. Hypercoagulability in IBD might be associated not only with the inflammatory process but also with disturbances in the anti-coagulant system, since defection in PC pathway was found both in active and non-active disease.   
Danuta Owczarek; Dorota Cibor; Kinga Sałapa; Andrzej Cieśla; Mikołaj K Głowacki; Halina Pocztar; Tomasz Mach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-24
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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