| Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: Folk medicinal use to scientific approach. | |
| | |
MedLine Citation:
|
PMID: 23336600 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context: Pisonia aculeata leaves (Nyctagenaceae), a Folk medicinal plant used in the treatment of several inflammation, pain, and oxidative stress associated diseases. Objective: To evaluate anti-inflammatory, analgesic, and antioxidant potential of crude methanol extract of P. aculeata leaves (MEPA). Materials and methods: Analgesic and anti-inflammatory activities of MEPA (250 and 500 mg/kg) were evaluated using writhing, formalin, hot plate, tail flick, carrageenan-induced paw edema test, and membrane stabilizing activity. Free radical scavenging activity, total phenolic and flavonoid contents of MEPA were also determined using standard methods. Results: Oral administration of MEPA showed significant (p < 0.001) inhibition of paw edema, pronounced at 4 h and 5 h after carrageenan injection, and at 200 µg/mL exerts 77.67 and 38.51% protective effect against hypotonic solution and heat induced hemolysis, respectively. MEPA (250 and 500 mg/kg) produced 35.21 and 79.14% inhibition of acetic acid-induced writhing. Furthermore, MEPA (500 mg/kg) inhibited 49.19% early and 73.14% late phase of formalin-induced hypernociception. In contrast, a lower dose of MEPA did not prevent hot plate induced nociception, while in the tail immersion method, pronounced analgesic activity was observed between 1 and 4 h postdosing. The extract possesses significant in vitro antioxidant activity and a lipid peroxidation inhibition effect. Total phenolic and total flavonoid content in MEPA were 87.99 ± 0.87 mg GAE/g and 58.98 ± 0.01 mg QE/g, respectively. Discussion and conclusion: Our findings confirmed the analgesic, anti-inflammatory and antioxidant activities of Pisonia aculeata leaves. Contents of flavonoids and phenolic compounds in extract could be correlated with its observed biological activities. |
| | |
Authors:
|
Saikat Sen; Raja Chakraborty; B Rekha; D Revathi; S Chinna Ayyanna; G Hemalatha; G Ashok Kumar Reddy; S Hyndavi; P Jeevan Ikhyatha Babu; P Ravi Prakash; C Sridhar |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-22 |
Journal Detail:
|
Title: Pharmaceutical biology Volume: - ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pharmacology, Creative Educational Society's College of Pharmacy , Chinnatekur, Kurnool, Andhra Pradesh - 518218 , India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of candidate plasticity-related gene 15 is increased following traumatic brain injury.
Next Document: The physical and psychological impact of using a computer-based environmental control system: a case...