Document Detail


Anti-inflammatory, analgesic and anti-oedematous effects of Lafoensia pacari extract and ellagic acid.
MedLine Citation:
PMID:  16945186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lafoensia pacari St. Hil. (Lythraceae) is used in traditional medicine to treat inflammation. Previously, we demonstrated the anti-inflammatory effect that the ethanolic extract of L. pacari has in Toxocara canis infection (a model of systemic eosinophilia). In this study, we tested the anti-inflammatory activity of the same L. pacari extract in mice injected intraperitoneally with beta-glucan present in fraction 1 (F1) of the Histoplasma capsulatum cell wall (a model of acute eosinophilic inflammation). We also determined the anti-oedematous, analgesic and anti-pyretic effects of L. pacari extract in carrageenan-induced paw oedema, acetic acid writhing and LPS-induced fever, respectively. L. pacari extract significantly inhibited leucocyte recruitment into the peritoneal cavity induced by beta-glucan. In addition, the L. pacari extract presented significant analgesic, anti-oedematous and anti-pyretic effects. Bioassay-guided fractionation of the L. pacari extract in the F1 model led us to identify ellagic acid. As did the extract, ellagic acid presented anti-inflammatory, anti-oedematous and analgesic effects. However, ellagic acid had no anti-pyretic effect, suggesting that other compounds present in the plant stem are responsible for this effect. Nevertheless, our results demonstrate potential therapeutic effects of L. pacari extract and ellagic acid, providing new prospects for the development of drugs to treat pain, oedema and inflammation.
Authors:
Alexandre P Rogerio; Caroline Fontanari; Mirian C C Melo; Sérgio R Ambrosio; Glória E P de Souza; Paulo S Pereira; Suzelei C França; Fernando B da Costa; Deijanira A Albuquerque; Lúcia H Faccioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  58     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-01     Completed Date:  2006-12-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1265-73     Citation Subset:  IM    
Affiliation:
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Av. do Café s/n, Ribeirão Preto, SP, 14040-903, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid
Analgesics / isolation & purification,  pharmacology*
Animals
Anti-Inflammatory Agents / isolation & purification,  pharmacology*
Carrageenan
Edema / chemically induced,  prevention & control
Ellagic Acid / isolation & purification,  pharmacology*
Female
Fever / chemically induced,  prevention & control
Lipopolysaccharides
Lythraceae*
Male
Mice
Mice, Inbred BALB C
Pain / chemically induced,  prevention & control
Pain Measurement
Peritonitis / chemically induced,  prevention & control
Plant Bark
Plant Extracts / pharmacology
Plant Stems
Rats
Rats, Wistar
Time Factors
beta-Glucans
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Lipopolysaccharides; 0/Plant Extracts; 0/beta-Glucans; 476-66-4/Ellagic Acid; 64-19-7/Acetic Acid; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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